Key Longitudinal Associations With Risk and Glioblastoma Outcomes
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 200
- 试验地点
- 1
- 主要终点
- Overall Survival
研究概览
简要总结
The goal of this observational study is to find out what factors affect the health and risks in adults with glioblastoma (GBM), a grade 4 brain cancer.
The main questions it aims to answer are:
- How do genetic and immune system factors impact survival and quality of life in GBM patients?
- What occupational and medical history factors are linked to the risk of getting GBM?
Participants will:
- Fill out an online survey about their medical history and lifestyle.
Participants will have the chance to give a blood sample (from the outer arm) for genetic and immune system testing. Blood samples will be given using a home collection kit provided by the study team.
详细描述
This observational study aims to investigate the various factors influencing outcomes and risks in adults diagnosed with glioblastoma (GBM). Glioblastoma is a highly aggressive and malignant brain tumor, and understanding the factors that affect patient outcomes is crucial for improving management strategies and patient care.
The study employs a case-only design where participants will be followed over time to observe how different factors affect their health outcomes. Participants will be selected based on their diagnosis of glioblastoma and will be included in the study regardless of current treatment status or disease stage.
Findings from this study are expected to provide valuable insights into the factors affecting glioblastoma outcomes and may contribute to the development of personalized treatment strategies and risk assessment tools for better management of the disease.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •At least 18 years old
- •Pathologically-confirmed diagnosis of glioblastoma multiforme (GBM) or grade 4 brain tumor
- •Participant is accessible for follow-up (has a working email address)
- •Participant is willing and able to comply with the study requirements
排除标准
- •Those who cannot read either English or Spanish
- •Those who cannot view an online survey
研究组 & 干预措施
Adults with Glioblastoma
This group consists of adults diagnosed with glioblastoma, a type of aggressive brain tumor. Participants are observed to identify factors influencing their outcomes, including genetic, immunologic, and personal medical history factors. The study aims to explore how these factors impact survival rates and quality of life in this patient population. There are no specific interventions. Instead, the focus is on analyzing survey data and biological samples to understand risk factors and disease progression.
结局指标
主要结局
Overall Survival
时间窗: From date of enrollment until date of death from any cause as submitted by caregiver, up to 60 months
Overall survival will be estimated using patient-reported date of diagnosis and assessed in three month intervals until patients are reported as deceased or are lost to follow-up
Functional Well-being as measured by the Functional Assessment of Cancer Therapy-Brain (FACT-Br) questionnaire
时间窗: At time of study enrollment
Estimated using the functional well-being subscale of the FACT-Br questionnaire. The score ranges from 0 to 28, where a higher score indicates greater functional well-being.
次要结局
未报告次要终点