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Clinical Trials/NCT01342588
NCT01342588
Unknown
N/A

Accuracy of Lumbar Pedicle Screw Placement Assisted With Continuous Pulse-train Stimulation During Track Creation and Screw Insertion

American British Cowdray Medical Center1 site in 1 country60 target enrollmentJanuary 2011

Overview

Phase
N/A
Intervention
Not specified
Conditions
Spine Pedicle Screw Placement
Sponsor
American British Cowdray Medical Center
Enrollment
60
Locations
1
Primary Endpoint
Intra operative neurophysiological monitoring (IONM) alert
Last Updated
15 years ago

Overview

Brief Summary

The purpose of this study is to establish the accuracy of pedicle positioning using continuous electrical pulse during screwing. Additionally, the investigators evaluate if this maneuver can prevent neurological injury during track creation and screwing in lumbar and thoracic spine instrumentation surgery

Detailed Description

Pedicle screw instrumentation as part of spine surgery is a recurrent technique used for most of spine surgeons. Since its description by Boucher in 1959 and its popularization later by Roy-Camille, has been considered a technique that demands great anatomy knowledge and some grade of expertise. Even in experienced hands the misplacement of pedicle screws could have an incidence of 10-40% (average of 20%). Medially misplacements during track creation and screw insertion are the most feared complications, because the anatomic relationship between medial pedicle wall and neural structures. The first attempt to use continuous electrical stimulation during pedicle track creation and screw insertion was communicated in 1997 by Welch WC, et al. In that study they used the bone impedance as a direct measurement of pedicle wall integrity; unfortunately they used inhaled anesthetics and assessed the final screw position with plain X-rays. They reported a sensibility and specificity of 98% and 99% respectively. The great limitation for this study is its assessment of screw accuracy performed by plain X-rays, now a days the best way to do it is with computed tomography (CT). After the Welch report, a couple of studies more have used similar techniques in the thoracic spine trying to avoid neurological injuries during pedicle screw insertion, but none described the use of continuous train pulses during screwing. The present study pretends to evaluate the final accuracy and trans-operative usefulness of the pulse train stimulation during track creation and screw insertion using intra venous anesthetic agents and CT scans to assess the integrity of pedicle walls

Registry
clinicaltrials.gov
Start Date
January 2011
End Date
May 2012
Last Updated
15 years ago
Study Type
Interventional
Study Design
Single Group
Sex
All

Investigators

Sponsor
American British Cowdray Medical Center

Eligibility Criteria

Inclusion Criteria

  • Any patient who needs pedicle screw placement for any spine condition

Exclusion Criteria

  • Previous spine surgery
  • Pedicle fracture documented before or during surgery.
  • Preoperative identified neurological deficit of the nerve roots close to the instrumented levels

Outcomes

Primary Outcomes

Intra operative neurophysiological monitoring (IONM) alert

Time Frame: Participants will be followed for the duration of surgical procedure, an expected average of 3-4 hours

- Continuous electrical stimulation delivered by a wire connected to the surgical instruments only during pedicle track creation and screw placement combined with neurophysiological monitoring will let us identify any IONM alert, defined as nerve irritation or a decrease in voltage and/or amplitude response. This is a single and immediate measurement obtained at surgery during spinal screw placement.

Secondary Outcomes

  • Pedicle screw accuracy(On day 2 after surgery before patient discharge, a CT scan will be performed)

Study Sites (1)

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