Structural and Molecular Neuroplasticity in Migraine
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Migraine
- Sponsor
- University of Michigan
- Enrollment
- 32
- Locations
- 1
- Primary Endpoint
- Level of mu-opioid receptor binding potential in the brain of episodic migraineurs during and outside the headache attack and compared to healthy controls.
- Status
- Completed
- Last Updated
- 8 years ago
Overview
Brief Summary
The main purpose of this study is to integrate novel MRI techniques with positron emission tomography(PET) for the study of structural and molecular neuroplasticity in the brain of migraineurs, and its clinical association with changes in pain perception and modulation (e.g. allodynia). We will attempt to acquire images of the brain that may, in the future, assist doctors in better understanding how pain is felt and regulated in migraine sufferers.
Detailed Description
To investigate interictal opioid receptor (MOR) binding potential (BPND) changes in migraineurs as compared to age/gender-matched healthy controls. To demonstrate that frequency of the headache attacks and severity of cutaneous allodynia levels in migraineurs experienced over multiple attacks are correlated with levels of MOR BPND in specific brain regions. To investigate whether dysfunction of the pain regulatory endogenous opioid system of migraineurs is correlated with changes in the gray matter thickness in cortical areas associated with pain perception and modulation.
Investigators
Alexandre DaSilva, DDS, MS
Principal Investigator, Director of Headache and Orofacial Pain Effort
University of Michigan
Eligibility Criteria
Inclusion Criteria
- •Between 18-45 years of age
- •Between 1-14 migraine attacks per month or healthy
Exclusion Criteria
- •Cannot be taking daily migraine medication
- •Healthy subjects cannot be taking hormonal birth control pills or other medication
- •Cannot have chronic pain or a neurologic/psychiatric disorder such as: multiple sclerosis and bipolar disorder.
Outcomes
Primary Outcomes
Level of mu-opioid receptor binding potential in the brain of episodic migraineurs during and outside the headache attack and compared to healthy controls.
Time Frame: 90 min PET scan
Secondary Outcomes
- Correlation of migraine attack severity in migraineurs with mu-opioid receptor binding potential(90 min PET scan)