Molecular and Functional Neurobiology of Physical Exercise

Turku University Hospital1 site in 1 country24 target enrollmentApril 2013

ConditionsPhysical Exercise Behavior (Liking/Aversion)

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Physical Exercise Behavior (Liking/Aversion)
Sponsor: Turku University Hospital
Enrollment: 24
Locations: 1
Primary Endpoint: Binding of [11C]carfentanil in brain confirmed by positron emission tomography
Status: Completed
Last Updated: 5 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

In this study, we use positron emission tomography (PET) and functional magnetic resonance imaging (fMRI) to study brain mechanisms that contribute to physical exercise-induced reward. We examine whether acute physical exercise releases endogenous opioids in the brain, and whether it modulates brain responses to viewing appetizing foods. Unraveling these mechanism are instrumental from a public health perspective, given the undisputed positive health effects of physical exercise.

Registry

clinicaltrials.gov

Start Date

April 2013

End Date

June 2018

Last Updated

5 years ago

Study Type

Interventional

Study Design

Single Group

Sex

Male

Investigators

Sponsor

Turku University Hospital

Responsible Party

Sponsor

Eligibility Criteria

Inclusion Criteria

•Native Finnish speaker
•Age \> 18 years
•Western Caucasian origin

Exclusion Criteria

•Age \< 18 or \> 65
•History or current mental disorder
•BMI \> 27 kg/m2
•Use of drugs that influence the central nervous system, including nicotine
•Poor compliance
•Any chronic medical defect or injury which hinder or interfere everyday life
•Eating disorder
•Current or past excessive use of alcohol or substance abuse
•Past dose of radiation from medical research such that the annual effective dose will exceed 10 mSv
•Any other condition that in the opinion of the investigator could create a hazard to the subject safety, endanger the study procedures or interfere with the interpretation of study results