Does nitrite reduce ischaemia-reperfusion injury in patients with acute ST segment elevation myocaridal infarction? - NIAMI - Nitrites in Acute Myocardial Infarction

niversity of Aberdeen0 个研究点目标入组 280 人开始时间: 2011年1月10日最近更新: 2019年6月30日

适应症

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•Men aged >=18 years and women aged >=55 years presenting within 12 hours of the onset of chest pain who have ST segment elevation of more than 0.1mV and for whom the clinical decision has been made to treat with primary PCI will be eligible for enrolment. Occlusion of the culprit related artery (TIMI grade 0 or grade 1) will also be required for inclusion. Eligible patients will be of North European descent.
•Are the trial subjects under 18? no
•Number of subjects for this age range:
•F.1.2 Adults (18-64 years) yes
•F.1.2.1 Number of subjects for this age range
•F.1.3 Elderly (>=65 years) yes
•F.1.3.1 Number of subjects for this age range

•The exclusion criteria are:
•Historical or ECG evidence of previous myocardial infarction
•Prior revascularization procedure
•Known or suspected pregnancy
•Atrial fibrillation at time of randomization
•Contra-indications to MRI
•Patients with cardiac arrest or cardiogenic shock
•Patients with left main coronary occlusion
•Patients with known moderate to severe renal failure (estimated GFR < 30mls/min), or liver failure.

发起方

niversity of Aberdeen