Circadian rhythms of glucose metabolism, adipose gene expression and coagulation in type 2 diabetes

Completed

• Conditions: diabetes; metabolic syndrome; 10011082; 10018424; 10003216

• Registration Number: NL-OMON35845
• Lead Sponsor: Academisch Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 29 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 12

Inclusion Criteria

Patients: Male, type 2 diabetes, Age 30-75 yr, BMI 25-40 kg/m2
Controls: Male, Age 30-75 yr , BMI <25 kg/m2

Exclusion Criteria

Patients:
Use of any other anti-diabetic drug than metformin
Acute or chronic metabolic disease (other than type 2 diabetes) that will impair metabolism or digestion and absorption of food, including gastro-intestinal, hepatic or renal disease
Inability to give informed consent
Shift work in the month before intervention
Crossing several timezones in the month before intervention;Controls
Any acute or chronic metabolic disease that will impair metabolism or digestion and absorption of food, including gastro-intestinal, hepatic or renal disease
Inability to give informed consent
Shift work in the month before intervention
Crossing several timezones in the month before intervention

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Difference between patients and controls in circadian glucose excursions,<br /><br>hemostasis, and gene expression profiles in adipose tissue. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>n/a</p><br>