Effects of Acute Red Raspberry Consumption on Vascular Function in Healthy Individuals
- Conditions
- Healthy
- Interventions
- Dietary Supplement: 400 g frozen raspberriesDietary Supplement: 200 g frozen raspberriesDietary Supplement: Placebo
- Registration Number
- NCT02734901
- Lead Sponsor
- Heinrich-Heine University, Duesseldorf
- Brief Summary
Accumulating evidence from epidemiological and human intervention studies indicates that the cardiovascular health benefits of diets rich in fruits and vegetables are (in part) related to their (poly)phenol content. Raspberries are rich in phenolic and polyphenolic compounds, in particular procyanidins, ellagitannins and anthocyanins, but also phenolic acids. At present, a small number of randomized controlled trials investigating the effects of berry (poly)phenols on validated surrogate markers of cardiovascular disease risk have shown promising results. However, to date, very few human studies have specifically investigated the effects of raspberry (poly)phenols on cardiovascular function in healthy subjects. Moreover, ellagitannin-derived metabolites are believed to persist for a long period of time in the blood and urine. Therefore, the investigators will investigate the presence of plasma and urinary raspberry-derived metabolites 24h post-consumption. To the investigators knowledge, the effects of red raspberry consumption on vascular function in humans have not been investigated before. This information is necessary for the planning of long-term studies aiming to assess the potential beneficial effects of raspberries,. Therefore, this study aims to investigate the potential role of red raspberry (poly)phenols in the modulation of vascular function by monitoring changes in vascular function together with the major (poly)phenol derivatives/metabolites in plasma.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Male
- Target Recruitment
- 10
- healthy male subjects (no clinical signs or symptoms of cardiovascular disease)
- Cardiovascular disease
- acute inflammation
- cardiac arrhythmia
- renal failure
- heart failure (NYHA II-IV)
- diabetes mellitus
- C - reactive protein > 05 mg/dL
- malignant disease
- raspberry allergy/intolerance
- hypotension (≤100 / 60 mm Hg)
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description 400 g frozen raspberries 400 g frozen raspberries Red raspberry beverage Acute intake of 600 mL (1x daily) 200 g frozen raspberries 200 g frozen raspberries Red raspberry beverage Acute intake of 600 mL (1x daily) Placebo control Placebo Raspberry deprived supplement Acute intake of 600 mL (1x daily)
- Primary Outcome Measures
Name Time Method Change from baseline to 2 hour and 24 hour in Endothelial function Baseline, 2 hour and 24 hour measured by flow mediated dilation (FMD) on baseline at 2 and 24 hour postconsumption
- Secondary Outcome Measures
Name Time Method Change from baseline to 2 hour and 24 hour in Pulse wave velocity Baseline, 2 hour and 24 hour measured by sphygmomanometer SphygmoCor on baseline at 2 and 24 hours postconsumption
Change from baseline to 2 hour and 24 hour in Heart rate Baseline, 2 hour and 24 hour measured by SphygmoCor on baseline at 2 and 24 hours postconsumption
Change from baseline to 2 hour and 24 hour in Central blood pressure Baseline, 2 hour and 24 hour measured by sphygmomanometer SphygmoCor on baseline at 2 and 24 hours postconsumption
Peripheral blood pressure Baseline, 2 h and 24 h measured by automatic sphygmomanometer on baseline at 2 and 24 hours postconsumption
Trial Locations
- Locations (1)
Division of Cardiology, Pulmonary Disease and Vascular Medicine, University Hospital Duesseldorf
🇩🇪Duesseldorf, Germany