Proof-of-Concept Study of Insulin Glargine as Basal Insulin Support for Recovering Critically Ill Patients

Phase 4

• Conditions: stress diabetes in critical illness; Metabolic and Endocrine - Diabetes

• Registration Number: ACTRN12610000574044
• Lead Sponsor: Canterbury District Health Board/Christchurch Hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2010-07-16
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: ot yet recruiting
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

Stable hourly insulin requirement, equal to or less than 3U of intravenous insulin per hour, for at least 12 hours.
- Stable naso-gastric feed rate, equal to or greater than 60% of the calculated goal feed. (Goal feed is calculated using individual patient’s age, gender and frame size.)
- No acute renal failure (creatinine < 250 micromol/L)
- Less than 1000ml of fluid given as intravenous boluses in the past 24 hours, indicating stable interstitial volume.
- Resolving multiple organ failure (Sequential Organ Failure Assessment Score SOFA<=6).

Exclusion Criteria

insulin dependent diabetes, absence of an arterial line, not expected to survive for more than 3 days at the time of screening

Study & Design

• Study Type: Interventional
• Study Design: Not specified