DRKS00024838尚未招募不适用
Myeloid Cells` Immunosuppressive activity in Sepsis - MyCIS
Klinik für Anästhesiologie - Universitätsklinikum Heidelberg0 个研究点目标入组 100 人开始时间: 2021年3月30日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 100
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18 Years 至 one（—）
- 性别
- All
入选标准
- •Patients with Sepsis:
- •Consent by the legal representative
- •At least 2 SIRS criteria met:
- •- temperature <36ºC or> 38ºC
- •- tachycardia (> 90 /min)
- •- leukocytosis (> 12,000 /µl) OR leukopenia (<4,000 /µl) OR left shift (>10% immature blasts)
- •- Tachypnea (> 20 /min) OR paCO2 <32 mmHg OR oxygenation index (FiO2/paO2) <200 OR mechanical Ventilation
- •Clinical or microbiological evidence of infection
- •Sepsis-associated organ dysfunction indicated by a change in the Sequential Organ Failure Assessment (SOFA) score by 2 or more points (compared to previous day)
- •Healthy volunteers:
- •Informed consent
排除标准
- •Common exclusion criteria of all study groups:
- •Inclusion in an interventional study
- •Infectious viral diseases (HBV, HCV, HIV)
- •Iatrogenic immunosuppression
- •Pre-existing autoimmune diseases
- •Treatment with checkpoint inhibitors
- •Specific exclusion criteria of patients with sepsis:
- •Diagnosis sepsis >24 h.
- •Specific exclusion criteria of healthy volunteers:
- •One of the following states during the last 7 days:
- •- Influenza infection or flu
- •- Sports injuries or other trauma
- •- Large-scale dental interventions (e.g., tooth extraction)
- •- Blood or platelet donation.
研究者
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