Myeloid Suppressors in Inflammation

Completed

• Conditions: Asthma

• Registration Number: NCT01224223
• Lead Sponsor: University of South Florida

Brief Summary

Myeloid-derived suppressor cells (MDSC) have been studied for their ability to suppress T cell responses in vivo and in vitro. As a result, MDSC can regulate cellular responses to chronic inflammatory conditions such as cancer, leading to the induction of tolerance and, ultimately, tumor escape from immune surveillance.

Detailed Description

Not available

Study Timeline

• Status Verified: 2010-10
• Study Start: 2010-10
• Study First Submitted: 2010-10-18
• Study First Submitted QC: 2010-10-18
• Study First Posted: 2010-10-19
• Primary Completion: 2012-01
• Study Completion: 2012-01
• Last Update Submitted: 2012-06-27
• Last Update Posted: 2012-06-28

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

Not provided

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Exclusion Criteria

1. Use of systemic corticosteroids within the previous two weeks.
2. Pregnant and/or lactating females.
3. Current tobacco use.
4. Severe psychiatric illness.
5. Current illicit substance abuse or dependence and/or abuse of alcohol.
6. Current use of anti-microbial medications.
7. Primary or secondary immunodeficiency.
8. Any clinically significant uncontrolled medical condition that would put the patient's safety at risk.

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To identify and characterize specific cell types (human dendritic cells, myeloid-derived suppressor cells and T lymphocytes) that are present in acute and chronic asthma.	one year from start of study

Trial Locations

Locations (1)

USF Asthma, Allergy and Immunology CRU; 🇺🇸 Tampa, Florida, United States