Prefrontal mechanisms underlying the effects of positive and negative expectation on pain: a combined EEG-fMRI study
Not Applicable
- Conditions
- Pain and Pain Treatment
- Registration Number
- DRKS00025872
- Lead Sponsor
- niversitätsklinikum Hamburg-Eppendorf
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 55
Inclusion Criteria
Healthy adults with normal or corrected-to-normal vision, right-handed
Exclusion Criteria
- any contraindications for MRI measurement (metal implants, non-removable piercings, heart pacemaker, tattoos close to the head, known claustrophobia)
- red-green deficiency
- chronic or acute disease or pain
- neurological or psychiatric disorders
- pregnancy
- regular medication intake (except contraceptive), recent use of psychotropic or analgesic substances
- use of illegal drugs
- consumption of caffeine 2 hours before MRI testing and consumption of alcohol on the day of testing and the previous day
- smoking
- participation in any medication-associated experimental study in the last 6 months
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Our aim is to assess time-frequency (EEG) and spatial (fMRI) neural characteristics of positive and negative expectations on pain in the expectation phase prior to the application of painful stimuli.
- Secondary Outcome Measures
Name Time Method In addition, we will examine the neural processes after the cue presentation and after the application of the pain stimuli.