Study of N-acetylcysteine effects on oxidative stress markers and renal function in cadaveric kidney transplantatio
Not Applicable
- Conditions
- patients on maintenance-hemodialysis who are undergoing cadaveric kidney transplantation.Kidney transplant status
- Registration Number
- IRCT2016081827346N4
- Lead Sponsor
- Vice chancellor for research, Shahid Beheshti University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 60
Inclusion Criteria
Patients on maintenance dialysis who are undergoing cadaveric renal transplantation
Exclusion criteria: preemptive kidney transplantation (transplantation prior to initiation of dialysis), multi-organ transplants, second transplantation, history of using NAC within the month prior to operation, and history of sensitivity to sulfa drugs
Exclusion Criteria
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Glutathione peroxidase activity in erythrocytes and serum malondialdehyde levels. Timepoint: pre-transplantation and 5 days after transplantation. Method of measurement: Randox Laboratories commercial kits for Glutathione peroxidase and biochemical method for malondialdehyde.
- Secondary Outcome Measures
Name Time Method Serum creatinine. Timepoint: daily. Method of measurement: biochemical method.