Atropine-effect During Propofol/Remifentanil Induction

Not Applicable

Completed

• Conditions: Anesthesia-induced Negative Hemodynamic Effects
• Interventions: Drug: Placebo; Drug: Atropine

• Registration Number: NCT01871922
• Lead Sponsor: University Medical Center Groningen

Brief Summary

Remifentanil is a widely used potent intravenous opioid with the advantage of having a short time of action. Compared to other opiates however remifentanil generates more intense hemodynamic side-effects. In ophthalmic surgery the specific anesthesiological challenges necessitate the administration of a combination of relatively high doses of analgesics on the one hand and a short time for postoperative recovery from anesthesia on the other. For these reasons, anesthetic management often consists of a combination of relatively high doses of propofol and remifentanil. A primary concern during this deep propofol/remifentanil anesthesia is preserving hemodynamic stability and adequate tissue oxygenation. Previous research of the investigators group has revealed that atropine has an exceptionally beneficial effect on hemodynamics as well as on tissue oxygenation. Therefore, the investigators hypothesize that administration of intravenous atropine during induction of propofol/remifentanil may have a positive effect on the hemodynamic profile and peripheral and cerebral tissue oxygenation during and after induction of anesthesia.

Detailed Description

Not available

Study Timeline

• Study Start: 2012-10
• Study First Submitted: 2013-05-30
• Primary Completion: 2013-06
• Study Completion: 2013-06
• Study First Submitted QC: 2013-06-06
• Study First Posted: 2013-06-07
• Status Verified: 2024-04
• Last Update Submitted: 2024-04-15
• Last Update Posted: 2024-04-17

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• Patients requiring general anaesthesia;
• Patient's age ≥ 18 years and older;
• Patient and surgical procedure appropriate for treatment with either sufentanil or remifentanil.

Exclusion Criteria

• Patient's refusal;
• Pregnancy;
• Patient's age < 18 years;
• Patients in which atropine is contra-indicated, such as severe aortic valve stenosis, hypertrophic cardiomyopathy or coronary artery disease.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
General anesthesia + placebo	Placebo	Propofol/remifentanil anesthesia + saline
General anesthesia + atropine	Atropine	Propofol/remifentanil anesthesia + atropine

Primary Outcome Measures

Name	Time	Method
Cardiac output	During anesthesia
Cerebral tissue oxygen saturation	During anesthesia
Peripheral tissue oxygen saturation	During anesthesia

Secondary Outcome Measures

Name	Time	Method
Heart rate	During anesthesia
Mean arterial blood pressure	During anesthesia
Systemic vascular resistance	During anesthesia

Trial Locations

Locations (1)

University Medical Center Groningen; 🇳🇱 Groningen, Netherlands