Quizartinib or Placebo Plus Chemotherapy in Newly Diagnosed Patients With FLT3-ITD Negative AML
- Registration Number
- NCT06578247
- Lead Sponsor
- Daiichi Sankyo
- Brief Summary
This study will compare the effects of Quizartinib versus placebo in combination with chemotherapy in participants with newly diagnosed FMS-like tyrosine kinase 3 (FLT3)-internal tandem duplication (ITD) negative acute myeloid leukemia (AML).
- Detailed Description
This is a clinical trial to compare the effect of quizartinib versus placebo (administered with standard induction and consolidation chemotherapy, then administered as maintenance therapy for up to 36 cycles) on the primary endpoint of overall survival (OS) in adult patients with newly diagnosed FMS-like tyrosine kinase 3 (FLT3)-internal tandem duplication (ITD) negative acute myeloid leukemia (AML). Participants will be tested for FLT3-ITD mutation status in a central laboratory using a validated assay.
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 700
- Must be competent and able to comprehend, sign, and date an Ethics Committee (EC)- or Institutional Review Board (IRB)-approved Informed Consent Form (ICF) before performance of any trial-specific procedures or tests.
- ≥18 years or the minimum legal adult age (whichever is greater) and 70 years (at Screening).
- Newly diagnosed, morphologically documented primary AML based on the World Health Organization (WHO) 2016 classification (at Screening)
- Eastern Cooperative Oncology Group (ECOG) performance status (at the time the participant signs their ICF) of 0-2.
- Participant is receiving standard "7+3" induction chemotherapy regimen as specified in the protocol
Key
-
Diagnosis of acute promyelocytic leukemia (APL), French-American-British classification M3 or WHO classification of APL with translocation, t(15;17)(q22;q12), or BCR-ABL positive leukemia (ie, chronic myelogenous leukemia in blast crisis); participants who undergo diagnostic workup for APL and treatment with all-trans retinoic acid (ATRA), but who are found not to have APL, are eligible (treatment with ATRA must be discontinued before starting induction chemotherapy).
-
Diagnosis of AML secondary to prior chemotherapy or radiotherapy for other neoplasms or autoimmune/rheumatologic conditions.
-
Diagnosis of AML secondary to myelodysplastic syndrome (MDS) or a myeloproliferative neoplasm (MPN) or MDS/MPNs including CMML, aCML, JMML and others.
-
Participants with newly diagnosed AML with FLT3-ITD mutations (FLT3-ITD [+]) present at ≥5% VAF (or ≥0.05 SR) based on a validated FLT3 mutation assay.
-
Prior treatment for AML, except for the following allowances:
- Leukapheresis;
- Treatment for hyperleukocytosis with hydroxyurea;
- Cranial radiotherapy for central nervous system (CNS) leukostasis;
- Prophylactic intrathecal chemotherapy;
- Growth factor/cytokine support.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Arm A: Quizartinib + Chemotherapy Quizartinib Participants will receive quizartinib at 60 mg/day orally once daily for 14 days starting after the completion of chemotherapy in Induction and Consolidation Phase. In the Maintenance Phase, participants will receive quizartinib at 60 mg/day orally once daily for up to 36 cycles (28-day cycle) Arm C: Quizartinib + Chemotherapy then Placebo Maintenance Quizartinib Participants will receive quizartinib at 60 mg/day orally once daily for 14 days starting after the completion of chemotherapy in Induction and Consolidation Phase. In the Maintenance Phase, participants will receive placebo at 60 mg/day orally once daily for up to 36 cycles (28-day cycle) Arm C: Quizartinib + Chemotherapy then Placebo Maintenance Chemotherapy Participants will receive quizartinib at 60 mg/day orally once daily for 14 days starting after the completion of chemotherapy in Induction and Consolidation Phase. In the Maintenance Phase, participants will receive placebo at 60 mg/day orally once daily for up to 36 cycles (28-day cycle) Arm A: Quizartinib + Chemotherapy Chemotherapy Participants will receive quizartinib at 60 mg/day orally once daily for 14 days starting after the completion of chemotherapy in Induction and Consolidation Phase. In the Maintenance Phase, participants will receive quizartinib at 60 mg/day orally once daily for up to 36 cycles (28-day cycle) Arm C: Quizartinib + Chemotherapy then Placebo Maintenance Placebo Participants will receive quizartinib at 60 mg/day orally once daily for 14 days starting after the completion of chemotherapy in Induction and Consolidation Phase. In the Maintenance Phase, participants will receive placebo at 60 mg/day orally once daily for up to 36 cycles (28-day cycle) Arm B: Placebo + Chemotherapy Placebo Participants will receive placebo at 60 mg/day orally once daily for 14 days starting after the completion of chemotherapy in Induction and Consolidation Phase. In the Maintenance Phase, participants will receive placebo at 60 mg/day orally once daily for up to 36 cycles (28-day cycle) Arm B: Placebo + Chemotherapy Chemotherapy Participants will receive placebo at 60 mg/day orally once daily for 14 days starting after the completion of chemotherapy in Induction and Consolidation Phase. In the Maintenance Phase, participants will receive placebo at 60 mg/day orally once daily for up to 36 cycles (28-day cycle)
- Primary Outcome Measures
Name Time Method Overall Survival (Arm A vs Arm B) Date of first patient randomized to the target number of deaths reached, up to approximately 42 months Overall survival (OS) is defined as the time from randomization until death from any cause.
- Secondary Outcome Measures
Name Time Method Event-free survival (Arm A vs. Arm B) Date of randomization up to approximately 42 months Event-free survival (EFS) is defined as failure to achieve Complete Remission (CR) (as assessed by Independent Review Committee (IRC)) at end of induction, relapse after CR, or death due to any cause, whichever occurs first
Duration of complete response (Arm A vs. Arm B) Date of randomization up to approximately 42 months Duration of complete response (DoCR) is defined as time from the first documented CR until documented relapse or death due to any cause, whichever comes first
Relapse-free survival (Arm A vs. Arm B) Date of randomization up to approximately 42 months Relapse-free survival (RFS) is defined as time from randomization, for participants who achieve CR in the Induction Phase, until relapse or death due to any cause, whichever comes first
Complete remission rate (Arm A vs. Arm B) At end of Induction Phase, up to approximately 120 days Complete remission rate (CR) is defined as proportion of of participants who achieved a CR
Complete remission rate with minimal or measurable residual disease (Arm A vs. Arm B) At end of Induction Phase (Cycle 1 or Cycles 1 and 2) and at the end of 2 cycles (2 cycles of induction or 1 cycle induction and 1 cycle consolidation)(1 Induction cycle is up to 60 days, 1 Consolidation cycle is 28 days), up to approximately 120 days Proportion of participants achieving CR with minimal or measurable residual disease (MRD) negativity
Number of Participants With Treatment-emergent Adverse Events (Arm A vs. Arm B) Date of first dose up to 30 days after last dose, up to approximately 42 months Treatment-emergent adverse events (TEAE) are defined as those AEs with start or worsening date during the on-treatment period (from the first dose date of quizartinib/placebo to 30 days after the last dose date of quizartinib/placebo).
Trial Locations
- Locations (258)
Az Sint-Jan
🇧🇪Brugge, Belgium
Cepon - Centro de Pesquisas Oncolă"Gicas de Santa Catarina
🇧🇷FlorianĂłpolis, Brazil
Mayo Clinic - Phoenix
🇺🇸Phoenix, Arizona, United States
Chiba Aoba Municipal Hospital
🇯🇵Chiba-shi, Japan
City of Hope Phoenix
🇺🇸Goodyear, Arizona, United States
Townsville University Hospital
🇦🇺Douglas, Australia
University of Arizona Cancer Center
🇺🇸Tucson, Arizona, United States
Ucsf - School of Medicine
🇺🇸San Francisco, California, United States
Stanford University School of Medicine- Parent
🇺🇸Stanford, California, United States
Colorado Blood Cancer Institute
🇺🇸Denver, Colorado, United States
Yale University
🇺🇸New Haven, Connecticut, United States
Mayo Clinic Hospital
🇺🇸Jacksonville, Florida, United States
Florida Hospital Cancer Institute - Kissimmee
🇺🇸Kissimmee, Florida, United States
Tampa General Hospital
🇺🇸Tampa, Florida, United States
Moffit Cancer Center
🇺🇸Tampa, Florida, United States
Augusta University
🇺🇸Augusta, Georgia, United States
University of Illinois Hospital & Health Sciences System
🇺🇸Chicago, Illinois, United States
The University of Chicago Medical Center
🇺🇸Chicago, Illinois, United States
University of Kentucky
🇺🇸Lexington, Kentucky, United States
Ochsner Medical Center - New Orleans
🇺🇸New Orleans, Louisiana, United States
Johns Hopkins Hospital
🇺🇸Baltimore, Maryland, United States
University of Michigan Comprehensive Cancer Center Michigan Medicine
🇺🇸Ann Arbor, Michigan, United States
Henry Ford Hospital
🇺🇸Detroit, Michigan, United States
University of Minnesota Medical School - Twin Cities Campus
🇺🇸Minneapolis, Minnesota, United States
Mayo Clinic
🇺🇸Rochester, Minnesota, United States
Washington University
🇺🇸Saint Louis, Missouri, United States
Hackensack University Medical Center
🇺🇸Hackensack, New Jersey, United States
Thomas Jefferson Univ Hosp
🇺🇸Haddonfield, New Jersey, United States
St Vincent'S Hospital Melbourne
🇦🇺Darlinghurst, Australia
Roswell Park Comprehensive Cancer Center
🇺🇸Buffalo, New York, United States
Memorial Sloan Kettering Cancer Center - Main
🇺🇸New York, New York, United States
Upstate University Hospital
🇺🇸Syracuse, New York, United States
University of North Carolina Hospitals
🇺🇸Chapel Hill, North Carolina, United States
University of Cincinnati
🇺🇸Cincinnati, Ohio, United States
Cleveland Clinic Taussig Cancer Center
🇺🇸Cleveland, Ohio, United States
The James Cancer Hospital and Solove Research Institute
🇺🇸Columbus, Ohio, United States
Ohio Health Marion Area Physicians
🇺🇸Columbus, Ohio, United States
Oregon Health & Science University (Ohsu)
🇺🇸Portland, Oregon, United States
University of Pennsylvania
🇺🇸Philadelphia, Pennsylvania, United States
Upmc Hillman Cancer Center
🇺🇸Pittsburgh, Pennsylvania, United States
Rhode Island Hospital
🇺🇸Providence, Rhode Island, United States
Tristar Bone Marrow Transplant
🇺🇸Nashville, Tennessee, United States
South Austin Medical Center
🇺🇸Austin, Texas, United States
Houston Methodist Hospital
🇺🇸Houston, Texas, United States
The University of Texas Md Anderson Cancer Center
🇺🇸Houston, Texas, United States
Uva Health System
🇺🇸Charlottesville, Virginia, United States
Virginia Commonwealth University (Vcu) Massey Cancer Center
🇺🇸Richmond, Virginia, United States
Medical College of Wisconsin
🇺🇸Milwaukee, Wisconsin, United States
Royal Adelaide Hospital
🇦🇺Adelaide, Australia
Flinders Medical Centre (Fmc)
🇦🇺Bedford Park, Australia
Box Hill Hospital
🇦🇺Box Hill, Australia
Concord Repatriation General Hospital
🇦🇺Concord, Australia
Liverpool Hospital
🇦🇺Liverpool, Australia
The Alfred Hospital
🇦🇺Melbourne, Australia
Fiona Stanley Hospital
🇦🇺Murdoch, Australia
Sir Charles Gairdner Hospital
🇦🇺Perth, Australia
Princess Alexandra Hospital
🇦🇺Woolloongabba, Australia
Ordensklinikum Linz Gmbh - Elisabethinen
🇦🇹Linz, Austria
Lkh - Universită"Tsklinikum Der Pmu Salzburg
🇦🇹Salzburg, Austria
Hanusch Krankenhaus Der Wgkk Wien
🇦🇹Wien, Austria
Institut Jules Bordet
🇧🇪Anderlecht, Belgium
ZNA
🇧🇪Antwerpen, Belgium
Uz Leuven
🇧🇪Leuven, Belgium
Chu de Liă Ge
🇧🇪Liege, Belgium
AZ DELTA
🇧🇪Roeselare, Belgium
Unesp - Faculdade de Medicina Da Universidade Estadual Paulista - Campus Botucatu
🇧🇷Botucatu, Brazil
Centro de Hematologia E Hemoterapia - Hemocentro de Campinas - Unicamp
🇧🇷Campinas, Brazil
Hospital Erasto Gaertner - Liga Paranaense de Combate Ao Că'Ncer
🇧🇷Curitiba, Brazil
Huwc - Ufc - Hospital Universită Rio Walter Cantă Dio - Universidade Federal Do Ceară
🇧🇷Fortaleza, Brazil
Hc-Ufg - Hospital Das Clă Nicas Da Universidade Federal de Goiă S
🇧🇷Goiania, Brazil
Fundaã§Ã£O Doutor Amaral Carvalho
🇧🇷Jaú, Brazil
Hospital de Clă Nicas de Passo Fundo
🇧🇷Passo Fundo, Brazil
Santa Casa de Miserică"Rdia de Porto Alegre
🇧🇷Porto Alegre, Brazil
Hospital de Clă Nicas de Porto Alegre
🇧🇷Porto Alegre, Brazil
Hospital Ernesto Dornelles
🇧🇷Porto Alegre, Brazil
Inca - Instituto Nacional de Că'Ncer
🇧🇷Rio de Janeiro, Brazil
Fundacao Faculdade Regional de Medicina de Sao Jose Do Rio Preto
🇧🇷Sao Jose Rio Preto, Brazil
Icesp - Instituto Do Câncer Do Estado de São Paulo Octavio Frias de Oliveira
🇧🇷SĂŁo Paulo, Brazil
Hospital Benefică Ncia Portuguesa de Să O Paulo
🇧🇷SĂŁo Paulo, Brazil
Hospital Nove de Julho
🇧🇷SĂŁo Paulo, Brazil
Umhat 'Dr. Georgi Stranski', Ead
🇧🇬Pleven, Bulgaria
Umhat 'Sv. Georgi', Ead
🇧🇬Plovdiv, Bulgaria
Umhat  Sv. Ivan Rilskiâ , Ead
🇧🇬Sofia, Bulgaria
Military Medical Academy - Mhat - Sofia
🇧🇬Sofia, Bulgaria
'Shathd' Ead Sofia
🇧🇬Sofia, Bulgaria
Umhat Prof. Dr. Stoyan Kirkovich Ad
🇧🇬Stara Zagora, Bulgaria
London Health Sciences Centre
🇨🇦London, Canada
The Ottawa Hospital - General Campus
🇨🇦Ottawa, Canada
Saskatoon Cancer Centre
🇨🇦Saskatoon, Canada
Princess Margaret Cancer Center
🇨🇦Toronto, Canada
Peking University First Hospital
🇨🇳Beijing, China
Peking University Third Hospital
🇨🇳Beijing, China
Peking Union Medical College Hospital
🇨🇳Beijing, China
The First Hospital of Jilin University
🇨🇳Changchun, China
Xiangya Hospital, Central South University
🇨🇳Changsha, China
The Second Xiangya Hospital of Central South University
🇨🇳Changsha, China
The First Affiliated Hospital of Chongqing Medical University
🇨🇳Chongqing, China
Sun Yat-Sen University, Cancer Center
🇨🇳Guangzhou, China
Guangdong Provincial People'S Hospital
🇨🇳Guangzhou, China
Qilu Hospital of Shandong University
🇨🇳Jinan, China
The First Affiliated Hospital of Nanchang University
🇨🇳Nanchang, China
Zhong Da Hospital, Southeast University
🇨🇳Nanjing, China
Affiliated Hospital of Nantong University
🇨🇳Nantong, China
The Affiliated Hospital of Qingdao University
🇨🇳Qingdao, China
Shanghai Tongren Hospital
🇨🇳Shanghai, China
Shengjing Hospital of China Medical University
🇨🇳Shengyang, China
Shenzhen Second People'S Hospital
🇨🇳Shenzhen, China
The First Affiliated Hospital of Soochow University
🇨🇳Suzhou, China
Institute of Hematology and Hospital of Blood Disease
🇨🇳Tianjin, China
Tianjin Medical University General Hospital
🇨🇳Tianjin, China
The First Affiliated Hospital of Wenzhou Medical University
🇨🇳Wenzhou, China
Wuxi People'S Hospital
🇨🇳Wuxi, China
The First Affiliated Hospital of Xiâ An Jiaotong University
🇨🇳Xi'an, China
Yantai Yuhuangding Hospital
🇨🇳Yantai, China
Henan Cancer Hospital
🇨🇳Zhengzhou, China
Clinical Hospital Centre Rijeka
🇭🇷Rijeka, Croatia
Clinical Hospital Centar Zagreb
🇭🇷Zagreb, Croatia
Clinical Hospital Dubrava
🇭🇷Zagreb, Croatia
Fakultni Nemocnice Brno
🇨🇿Brno, Czechia
Fakultni Nemocnice Hradec Kralove
🇨🇿Hradec Kralove, Czechia
Fakultni Nemocnice Ostrava
🇨🇿Ostrava - Poruba, Czechia
Fakultni Nemocnice Plzen
🇨🇿Plzen, Czechia
Fakultni Nemocnice Kralovske Vinohrady
🇨🇿Praha 10, Czechia
Ustav Hematologie A Krevni Transfuze
🇨🇿Praha 2, Czechia
Chu Angers - Hă"Pital Hă"Tel Dieu
🇫🇷Angers, France
Chu de Caen
🇫🇷Caen, France
Chu de Grenoble - Hă"Pital Albert Michallon
🇫🇷Grenoble, France
Centre Hospitalier de Versailles
🇫🇷Le Chesnay Cedex, France
Hopital Claude Huriez - Chru Lille
🇫🇷Lille cedex, France
Centre Léon Bérard
🇫🇷Lyon, France
Hopital de La Conception - Aphm
🇫🇷Marseille Cedex 05, France
Chu de Nantes - Hotel Dieu
🇫🇷Nantes cedex 1, France
Chu Nice - Hă"Pital de L'Archet 1
🇫🇷Nice, France
Hă"Pital Saint-Louis
🇫🇷Paris cedex 10, France
Chu de Bordeaux - Hă"Pital Haut-Lă Vă Que
🇫🇷Pessac cedex, France
Centre Hospitalier Lyon Sud
🇫🇷Pierre BĂŠnite, France
Chu Rennes - Hopital Pontchaillou
🇫🇷Rennes cedex 09, France
Chu Amiens - Hopital Sud
🇫🇷Salouel, France
Institut de Cancă Rologie de Strasbourg Europe - Icans
🇫🇷Strasbourg, France
Institut Universitaire Du Cancer de Toulouse- Iuct-O
🇫🇷Toulouse, France
Klinikum Aschaffenburg-Alzenau
🇩🇪Alzenau, Germany
Staedtisches Klinikum Braunschweig Ggmbh
🇩🇪Braunschweig, Germany
Universitaetsklinikum Carl Gustav Carus Tu Dresden
🇩🇪Dresden, Germany
Universitaetsklinikum Essen
🇩🇪Essen, Germany
Krh Klinikum Siloah
🇩🇪Hannover, Germany
Universitaetsklinikum Heidelberg
🇩🇪Heidelberg, Germany
Universitaetsklinikum Schleswig-Holstein
🇩🇪Kiel, Germany
Universită"Tsklinikum Leipzig Klinik Fă R Hă"Matologie Internistische Onkologie Hă"Mostaseol
🇩🇪Leipzig, Germany
Universitaetsklinikum Muenster
🇩🇪Münster, Germany
The University of Hong Kong
🇭🇰Hong kong, Hong Kong
The Chinese University of Hong Kong (Cuhk)
🇭🇰Shatin, Hong Kong
Semmelweis Egyetem
🇭🇺Budapest, Hungary
Debreceni Egyetem
🇭🇺Debrecen, Hungary
Gyor-Moson-Sopron Varmegyei Petz Aladar Egyetemi Oktato Korhaz
🇭🇺Gyor, Hungary
Szegedi Tudomanyegyetem Szent-Gyorgyi Albert Klinikai Kozpont
🇭🇺Szeged, Hungary
Azienda Ospedaliero Universitaria Consorziale Policlinico Di Bari
🇮🇹Bari, Italy
Azienda Socio Sanitaria Territoriale Degli Spedali Civili Di Brescia (Presidio Spedali Civili)
🇮🇹Brescia, Italy
Irccs Istituto Scientifico Romagnolo Per Lo Studio Dei Tumori 'Dino Amadori' - Irst
🇮🇹Meldola, Italy
Ospedale San Raffaele
🇮🇹Milano, Italy
Azienda Socio Sanitaria Territoriale Niguarda (Grande Ospedale Metropolitano Niguarda)
🇮🇹Milano, Italy
Ospedale Maggiore Di Novara
🇮🇹Novara, Italy
Azienda Ospedaliera Vincenzo Cervello
🇮🇹Palermo, Italy
Fondazione Policlinico Universitario Agostino Gemelli Irccs
🇮🇹Roma, Italy
Azienda Ospedaliera Universitaria Policlinico Tor Vergata
🇮🇹Rome, Italy
Istituto Clinico Humanitas
🇮🇹Rozzano, Italy
Irccs Ospedale Casa Sollievo Della Sofferenza
🇮🇹San Giovanni Rotondo, Italy
Azienda Ospedaliero-Universitaria Cittă Della Salute E Della Scienza Di Torino
🇮🇹Torino, Italy
Ospedale Mauriziano Umberto I
🇮🇹Torino, Italy
Asst Dei Sette Laghi Ospedale Di Circolo E Fondazione Macchi Varese
🇮🇹Varese, Italy
Akita University Hospital
🇯🇵Akita, Japan
Aomori Prefetural Central Hospital
🇯🇵Aomori, Japan
Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital
🇯🇵Bunkyo-ku, Japan
Kyushu University Hospital
🇯🇵Fukuoka, Japan
Chugoku Central Hospital
🇯🇵Fukuyama, Japan
Gifu Municipal Hospital
🇯🇵Gifu, Japan
Hamamatsu University School of Medicine, University Hospital
🇯🇵Hamamatsu, Japan
Tesshokai Kameda General Hospital
🇯🇵Kamogawa-shi, Japan
Kanazawa University Hospital
🇯🇵Kanazawa, Japan
National Hospital Organization Kumamoto Medical Center
🇯🇵Kumamoto, Japan
Saiseikai Maebashi Hospital
🇯🇵Maebashi, Japan
Ehime Prefectural Central Hospital
🇯🇵Matsuyama, Japan
Nagoya University Hospital
🇯🇵Nagoya, Japan
Japan RED CROSS OSAKA HOSPITAL
🇯🇵Osakar, Japan
Hokkaido University Hospital
🇯🇵Sapporo, Japan
Sapporo Hokuyu Hospital
🇯🇵Sapporo, Japan
Tenri Hospital
🇯🇵Tenri, Japan
Inje University Haeundae Paik Hospital
🇰🇷Busan, Korea, Republic of
Pusan National University Hospital
🇰🇷Busan, Korea, Republic of
Kyungpook National University Chilgok Hospital
🇰🇷Daegu, Korea, Republic of
Yeungnam University Hospital
🇰🇷Daegu, Korea, Republic of
Daegu Catholic University Medical Center
🇰🇷Daegu, Korea, Republic of
Chonnam National University Hwasun Hospital
🇰🇷Hwasun-gun, Korea, Republic of
Gachon University Gil Medical Center
🇰🇷Incheon, Korea, Republic of
Jeonbuk National University Hospital
🇰🇷Jeonju-si, Korea, Republic of
Seoul National University Bundang Hospital
🇰🇷Seongnam-si, Korea, Republic of
Severance Hospital, Yonsei University Health System
🇰🇷Seoul, Korea, Republic of
Samsung Medical Center
🇰🇷Seoul, Korea, Republic of
The Catholic University of Korea, Seoul St. Mary'S Hospital
🇰🇷Seoul, Korea, Republic of
Korea University Guro Hospital
🇰🇷Seoul, Korea, Republic of
Seoul National University Hospital
🇰🇷Seoul, Korea, Republic of
Asan Medical Center
🇰🇷Seoul, Korea, Republic of
Ajou University Hospital
🇰🇷Suwon, Korea, Republic of
Ulsan University Hospital
🇰🇷Ulsan, Korea, Republic of
Haukeland Universitetssykehus
🇳🇴Bergen, Norway
Oslo University Hospital
🇳🇴Oslo, Norway
University Hospital of North Norway
🇳🇴Tromsø, Norway
Klinika Hematoonkologii I Transplantacji Szpiku
🇵🇱Lublin, Poland
Spzoz Msw Zwarmiĺ Sko-Mazurskimcen.Onko.Wolsztynie
🇵🇱Olsztyn, Poland
Wojewodzki Szpital Zespolony Im. L. Rydygiera W Toruniu
🇵🇱Torun, Poland
Instytut Hematologii I Transfuzjologii
🇵🇱Warszawa, Poland
Centro Hospitalar de Lisboa Norte, E.P.E. - Hospital de Santa Maria
🇵🇹Lisboa, Portugal
Instituto Português de Oncologia Do Porto Francisco Gentil, Epe
🇵🇹Porto, Portugal
Spitalul Clinic Colentina
🇷🇴Bucuresti, Romania
Institutul Clinic Fundeni
🇷🇴Bucuresti, Romania
Spitalul Clinic Coltea
🇷🇴Bucuresti, Romania
Institutul Oncologic Prof. Dr. Ion Chiricuta Cluj-Napoca
🇷🇴Cluj-Napoca, Romania
Spitalul Clinic Municipal Filantropia Craiova
🇷🇴Craiova, Romania
Military Medical Academy
🇷🇸Belgrade, Serbia
University Clinical Center of Serbia
🇷🇸Belgrade, Serbia
University Clinical Center Nis
🇷🇸Nis, Serbia
National University Hospital
🇸🇬Singapore, Singapore
Curie Oncology Pte Ltd
🇸🇬Singapore, Singapore
Complejo Hospitalario Universitario de Albacete
🇪🇸Albacete, Spain
Hospital de La Santa Creu I Sant Pau
🇪🇸Barcelona, Spain
Hospital San Pedro de Alcantara
🇪🇸Caceres, Spain
Hospital Universitario Reina Sofia
🇪🇸Cordoba, Spain
Hospital Universitario de Gran Canaria Dr. Negrin
🇪🇸Las Palmas, Spain
Clinica Universidad de Navarra
🇪🇸Madrid, Spain
Md Anderson Cancer Centre
🇪🇸Madrid, Spain
Hospital Universitario Fundacion Jimenez Diaz
🇪🇸Madrid, Spain
Hospital Universitario 12 de Octubre
🇪🇸Madrid, Spain
Hospital Universitario Puerta de Hierro Majadahonda
🇪🇸Majadahonda, Spain
Hospital Regional Universitario de Malaga
🇪🇸Malaga, Spain
Hospital General Universitario Morales Meseguer
🇪🇸Murcia, Spain
Hospital Universitari Son Espases
🇪🇸Palma de Mallorca, Spain
Hospital Universitario Quironsalud Madrid
🇪🇸Pozuelo de Alarcon, Spain
Hospital Universitario Marques de Valdecilla
🇪🇸Santander, Spain
Complejo Hospitalario Universitario de Santiago
🇪🇸Santiago de Compostela, Spain
Hospital Universitario Virgen Del Rocio
🇪🇸Seville, Spain
Hospital Clinico Universitario de Valencia
🇪🇸Valencia, Spain
Hospital Universitario Dr. Peset
🇪🇸Valencia, Spain
Hospital Universitari I Politecnic La Fe
🇪🇸Valencia, Spain
Sahlgrenska Universitetssjukhuset
🇸🇪GĂśteborg, Sweden
Skă Nes Universitetssjukhus, Lund
🇸🇪Lund, Sweden
Akademiska Sjukhuset
🇸🇪Uppsala, Sweden
Inselspital - Universitaetsspital Bern
🇨🇭Bern, Switzerland
Kaohsiung Chang Gung Memorial Hospital
🇨🇳Kaohsiung, Taiwan
China Medical University Hospital
🇨🇳Taichung, Taiwan
National Cheng Kung University Hospitalx
🇨🇳Tainan, Taiwan
National Taiwan University Hospital
🇨🇳Taipei, Taiwan
Taipei Veterans General Hospital
🇨🇳Taipei, Taiwan
Chang Gung Memorial Hospital
🇨🇳Taoyuan County, Taiwan
King'S College Hospital
🇬🇧London, United Kingdom
Hammersmith Hospital
🇬🇧London, United Kingdom
Maidstone Hospital
🇬🇧Maidstone, United Kingdom
Manchester Royal Infirmary
🇬🇧Manchester, United Kingdom
Churchill Hospital
🇬🇧Oxford, United Kingdom
Torbay Hospital
🇬🇧Torquay, United Kingdom