Biomarkers in Chronic Arthritis
- Conditions
- Chronic Arthritis
- Registration Number
- NCT02909998
- Lead Sponsor
- University Hospital, Montpellier
- Brief Summary
Use of genotyping for the optimization of treatment with biologics in chronic arthritis by looking for an association between certain alleles and response to treatment.
- Detailed Description
Chronic arthritis in children and in adults represent a public health problem in number and difficulty of treatment. 30% of patients are non-responders and / or relapse upon discontinuation of treatment. Some of these treatments are not always well tolerated, sometimes with infectious complications including tuberculosis limiting the use of biological therapies. This study will validate a battery of genetic markers to predict responders biotherapy, determine the prognosis of patients, these treatments are reserved for the most severe forms, and thus improve the care of patients.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 379
- All patients treated with biotherapy may be included in this study with all information necessary for regular medical consultations (filling specific monitoring by GPs questionnaires), physical therapists visits, occupational therapists, psychologists.. etc
- Patients treated with biological therapy for non rheumatic disease
- Other inflammatory diseases such as Crohn's disease
- Refusal to participate in the collection
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Proportion of responsive patients with a given polymorphism (%) At the inclusion
- Secondary Outcome Measures
Name Time Method Distribution of patients with a given biotherapy (%) At the inclusion Distribution of patients presenting a given polymorphism (%) At the inclusion