Personalized Risk Estimator for Rheumatoid Arthritis Family Study

Not Applicable

Completed

Interventions: Behavioral: General Rheumatoid Arthritis Education
Behavioral: PRE-RA Plus
Behavioral: PRE-RA

Brief Summary: The purpose of this study is to understand how personalized risk factors for rheumatoid arthritis (RA) may impact willingness to change behaviors associated with RA. The investigators have developed a personalized risk estimator for RA based on demographics, family history, biomarkers and behaviors related to RA risk. Eligible participants have a first degree relative with RA but do not have RA themselves. Participants who meet eligibility and consent to the study will be randomized to receive either standard information about RA, the online personalized RA risk tool, or the online personalized RA risk tool with guidance from a health educator. Participants will be followed to measure willingness to change RA risk behaviors. The investigators hypothesize that participants who receive the online personalized RA risk tool and health education will be more willing to change RA risk behaviors compared to participants that receive standard RA information.

Detailed Description: A risk tool for rheumatoid arthritis (RA) was developed to provide personalized risk communication that includes biomarker, genetic and lifestyle RA risk factors. This risk calculator is referred to as the Personalized Risk Estimator for Rheumatoid Arthritis (PRE-RA) which will be used in the PRE-RA Family Study. A 3-arm randomized trial will be conducted among 222 RA first degree relatives that will be followed for one year. Participants will be surveyed before and after RA education concerning (i) knowledge and attitudes about RA risk, (ii) decisional balance related to behaviors, and (iii) stage of behavior change concerning lifestyle risks.

At the initial study visit, participants will be randomly assigned to one of three arms. Arm 1 participants will receive general education about RA (comparison group). These participants will be followed to assess for willingness to change behaviors associated with RA risk. Arm 2 participants will receive personalized risk by the personalized RA risk tool (PRE-RA). These participants will be followed to assess for willingness to change RA risk behaviors. Arm 3 participants will receive personalized risk by the online risk tool along with health education and counseling (PRE-RA Plus group). These participants will be followed to assess for willingness to change RA risk behaviors.

Recruitment & Eligibility

Inclusion Criteria

Exclusion Criteria

Non-English speaking
Sign/symptoms of rheumatoid arthritis (assessed by screening questionnaire and study staff)
Rheumatoid arthritis
Systemic lupus erythematosus
Juvenile Idiopathic Arthritis
Psoriatic Arthritis
Ankylosing Spondylitis
Mixed Connective Tissue Disease
Reactive Arthritis
Adult-Onset Still's Disease
Sjogren's Syndrome
Dermatomyositis
Polymyositis
Polymyalgia Rheumatica
ANCA-associated Vasculitis
Giant Cell Arteritis
Polyarteritis Nodosa
Behcet's Disease
Relapsing Polychondritis

Arm && Interventions

Group	Intervention	Description
General Rheumatoid Arthritis Education	General Rheumatoid Arthritis Education	Arm 1 participants will receive general information about RA.
PRE-RA Plus	PRE-RA Plus	Arm 3 participants will receive personalized RA risk education by the PRE-RA risk tool and health educator.
PRE-RA	PRE-RA	Arm 2 participants will receive personalized RA risk education by the PRE-RA risk tool.

Primary Outcome Measures

Name	Time	Method
Contemplation Ladder	Immediately, 6 weeks, and 6 months after intervention	Measures willingness to change any of 4 RA-related behaviors compared to baseline using generalized estimating equations to compare the PRE-RA groups to the comparison arm.

Secondary Outcome Measures