Genetic and Social Network Correlates of Rheumatoid Arthritis Outcomes in Hispanic Populations: A Prospective Study
- Conditions
- Rheumatoid Arthritis
- Registration Number
- NCT05457816
- Lead Sponsor
- National Human Genome Research Institute (NHGRI)
- Brief Summary
Background:
Rheumatoid arthritis (RA) is more severe in Hispanic people. Genetics plays a role. But social issues may also lead to more severe RA in Hispanics. Some Hispanics may not seek help for early symptoms. Support from family and friends may persuade people to seek treatment earlier. Researchers want to learn more about how social factors affect RA in Hispanics.
Objective:
This natural history study will explore genetic and social factors related to RA in Hispanic families.
Eligibility: People aged 18 years or older of Hispanic/Latino heritage. They may have RA or RA symptoms; they may also have a relative or partner with RA or RA symptoms.
Design:
Participants will receive an email or text with a link to a 30-minute online survey. They will answer questions about these things:
Physical and emotional health
How health problems affect their life
Family history of RA and other conditions
Cultural identity and language preference
Participants may also answer these questions in a phone call or an in-person interview.
Participants will be asked to list people in their social network. They will answer questions about those relationships. They will be asked if they want to invite their family and friends to participate in the study.
If more than 1 person from a participant s family takes part in the study, they may be invited for an interview. They will answer questions about how arthritis pain affects their mind and body.
Participants will give a sample of saliva. They will spit into a vial. They will mail it in using a prepaid label.
- Detailed Description
Study Description:
Adult participants of Hispanic origin experiencing rheumatoid arthritis (RA) symptoms and their family members will be invited to participate in surveys and interviews to assess RA severity (affected individuals only), functional limitations, psychological well-being, use of health service, and family networks. Genotyping will be performed on saliva samples collected from consenting participants to evaluate genetic risk of severe RA in the population under study.
Objectives:
The primary objective is to identify the interpersonal mechanisms underlying RA-related health communication and health service use in Hispanic populations. The secondary objective is to characterize genetic risk of severe RA in Hispanic populations and determine how interpersonal mechanisms moderate such genetic risk.
Endpoints:
Primary Endpoint: Evaluate the associations between structural properties of the participants personal networks and RA-related health communication and use of health service
Secondary Endpoint: Evaluate the associations between family networks, RA-related health communication and use of health service, and RA severity across levels of genetic susceptibility
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 28
Not provided
Not provided
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Family networks One time Evaluate the associations between family networks, RA-related health communication and use of health service, and RA severity across levels of genetic susceptibility
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (2)
National Human Genome Research Institute (NHGRI)
🇺🇸Bethesda, Maryland, United States
National Institutes of Health Clinical Center
🇺🇸Bethesda, Maryland, United States