Multicenter Retrospective Observational Study of Acute Myocarditis in Korea

Completed

• Conditions: Myocarditis Acute

• Registration Number: NCT05933902
• Lead Sponsor: Samsung Medical Center

Brief Summary

In this study, the investigators analyze the clinical characteristics and prognosis of patients with acute myocarditis in South Korea

Detailed Description

Acute myocarditis refers to a condition in which inflammatory cells infiltrate the heart muscle due to various causes. Until now, there is no clear treatment method for myocarditis itself, and when myocardial function deteriorates or arrhythmia occurs due to myocarditis, it is common to wait for natural recovery while performing general supportive treatment for heart failure.

Through this study, the investigators analyze the factors contributing to the long-term prognosis, myocardial recovery rate, and clinical course of myocarditis. And, the investigators plan to establish an appropriate treatment strategy necessary to increase the survival rate of patients with myocarditis.

Study Timeline

• Study Start: 2022-04-12
• Primary Completion: 2023-01-25
• Study Completion: 2023-01-25
• Study First Submitted: 2023-05-12
• Status Verified: 2023-07
• Study First Submitted QC: 2023-07-03
• Last Update Submitted: 2023-07-03
• Study First Posted: 2023-07-06
• Last Update Posted: 2023-07-06

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 841

Inclusion Criteria

• Typical myocarditis symptom and sign, such as fever, chest pain, chest discomfort or shortness of breath, accompanied by elevated myocardial enzymes
• The above condition is satisfied and additional information is obtained through imaging such as cardiac MRI or cardiac biopsy

Exclusion Criteria

● Coronary artery disease

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Rate of In hospital mortality	through study completion, an average of 1 year	In hospital death by any cause

Secondary Outcome Measures

Name	Time	Method
Rate of all-cause mortality	through study completion, an average of 1 year	Death by any cause during follow-up
Requirement of cardiac replacement therapy	through study completion, an average of 1 year	Left ventricular assist device insertion or heart transplantation during follow-up
Rates of Re-hospitalization due to any cause	through study completion, an average of 1 year	Re-hospitalization due to any cause during follow-up

Trial Locations

Locations (1)

Samsung Medical Center; 🇰🇷 Seoul, Korea, Republic of