Application and Effect Evaluation of Medium Chain Fatty Acid Rich Milk Powder in Infants With Cholestatic Liver Disease
- Conditions
- Cholestatic Liver Disease
- Registration Number
- NCT05922332
- Lead Sponsor
- Children's Hospital of Fudan University
- Brief Summary
To verify the effect of feeding milk powder rich in medium chain fatty acids on improving the nutritional status and disease status of infants with cholestatic liver disease and To evaluate the safety of feeding milk powder rich in medium chain fatty acids in infants with cholestatic liver disease.
- Detailed Description
This study will include all types of cholestatic liver disease in infants, randomized controlled study of the efficacy and safety of intervention with rich medium chain fatty acid milk powder,To verify the effect of feeding milk powder rich in medium chain fatty acids on improving the nutritional status and disease status of infants with cholestatic liver disease .
Recruitment & Eligibility
- Status
- WITHDRAWN
- Sex
- All
- Target Recruitment
- 64
- meets the diagnostic criteria of cholestasis
- Artificial feeding (formula feeders)
- Age ≤6 months
- The course of cholestasis was > 1 month
- Informed consent of the guardian
- There are major non-cholestatic genetic diseases leading to nutritional intake disorders, such as gastrointestinal malformations
- Cholestasis with ascites and diarrhea
- In patients with oxidative impairment of medium chain fatty acids
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method Z-scores of weight for age "from enrollment to the 4 weekend(28 days)" The change of WAZ would be calculation at the 4 weekend(28 days) after enrollment.
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
zhaoyang Gou
🇨🇳Shanghai, China
zhaoyang Gou🇨🇳Shanghai, China