NCT02471092已完成不适用
The Effect of Milk Proteins on Satiety, Food Intake and Metabolic Control (Glycemia) in Early Adulthood
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 32
- 试验地点
- 2
- 主要终点
- Postprandial Glycemia, as measured by capillary blood glucose (mmol/L)
研究概览
简要总结
The purpose of this study is to develop and test modified milk protein products to determine the effects of amino acids on food intake, satiety, insulin secretion and glucose control by insulin-independent action in healthy adults.
详细描述
- A total of 33 males and females will participate in the study. Capillary blood samples will be collected from all participants to measure plasma glucose over a 3.5 hour postprandial study.
- Intravenous blood samples will be collected from a subset of 12 (6 males and 6 females) participants for determination of insulin, satiety hormones, acetaminophen (gastric emptying rates), and determination of amino acid profiles.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 30 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •BMI 20 - 24.9 kg/m2
- •Healthy as determined by screening questionnaire
- •Male or Female
- •Non-smoking
- •Normal fasting plasma glucose (<5.5 mmol/L), but not below 3.3 mmol/L.
- •Prior use of acetaminophen
排除标准
- •Gastrointestinal conditions or illness (including, but not limited to, lactose intolerance, Celiac, Crohn's, Ulcerative Colitis (UC), Irritable Bowel Disorder (IBD)
- •Weight loss or weight gain of more than 5 kg during the previous 2 months
- •Taking medication or protein supplements (excluding oral contraceptive, multivitamins and folic acid)
- •Serious medical condition (ie. Renal, liver)
- •Lack of appetite or skipping breakfast
- •Restrained eaters as defined as having a Three Factor Eating Questionnaire-Cognitive Restraint >16
- •Reported intolerance to milk or very low consumption (< 2 servings per week) as assessed by in-person screening. Or not liking of the research foods.
- •Food allergies or intolerances as well as anaphylactic or life-threatening allergies - food or otherwise
- •Diabetes or other metabolic diseases that could interfere with study outcomes
- •Acetaminophen, codeine or opioid allergy
- •Pregnant or Breast Feeding
- •Typical alcohol consumption of not more than 4 drinks per sitting
结局指标
主要结局
Postprandial Glycemia, as measured by capillary blood glucose (mmol/L)
时间窗: 0-200 minutes
次要结局
- Postprandial Satiety, as measured by paper 100-mm visual analogue scale (mm)(0-200 minutes)
- Food Intake at ad libitum lunch meal, as measured by weighed pizza consumption (g)(at 120 minutes)
研究者
Amanda Wright, Ph.D.
Associate Professor
University of Guelph
研究点 (2)
Loading locations...
相似试验
已完成
不适用
The Importance of Additional Protein to Benefit More From Training During and After HospitalizationSarcopeniaNCT02717819Forskningsenheden165
进行中（未招募）
不适用
The Effects of Milk Protein Versus Soy Protein on Essential Omega-3 Fatty Acid MetabolismNutrition, HealthyNCT05820256University of Guelph32
已完成
不适用
Effects of Milk Proteins on Protein Synthesis in Healthy Male Subjects Fed a Hypercaloric, High Sucrose DietObesityNCT02168218University of Lausanne12
已完成
不适用
Health Effects of Milk Proteins in Elderly SubjectsHealthyNCT02218333University of Oslo50
已完成
不适用
Milk and Milk-produce to Counteract the Loss of Muscle Mass and Function in Exercising Older Adults.SarcopeniaNCT01883674Université de Sherbrooke41