The influence of myeloperoxidase-deficiency on the vasculature
- Conditions
- Myeloperoxidase deficiency, parodontits, chronic inflammationEndothelial Dysfunction
- Registration Number
- DRKS00019108
- Lead Sponsor
- Medizinische Klinik III, Herzzentrum der Universität zu Köln
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- All
- Target Recruitment
- 200
Inclusion Criteria
MPXI deficient: = 18;
MPXI controls: = 10
Exclusion Criteria
minority (< 18 years), reduced ability to reason and capacity to contract, pregnancy
Study & Design
- Study Type
- observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Difference in endothelial function after parodontitis treatment evaluated bei FMD/NMD-measurement pre-treatment as well as day 1, week 8 and 6 months post treatment
- Secondary Outcome Measures
Name Time Method Blood levels of inflammatory parameters: <br>CRP, IL-6, BSR, MPO-levelsl, MPO-activity<br>pre treatment as well as day 1, week 8 and month 6 post treatment. <br><br>Evaluation of cardiovascular disease two years after study inclusion (anamnestically)