"Effects of Fluid Status and Regional Cerebral Oxygenation on Postoperative Cognitive Dysfunction in Patients Undergoing Lower Extremity Surgery Under General and Spinal Anesthesia."
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 发起方
- 入组人数
- 60
- 试验地点
- 2
- 主要终点
- Early postoperative period (24th and 48th hours) cognitive dysfunction rate
研究概览
简要总结
We frequently encounter cognitive impairments in patients over 65 undergoing Lower extremity surgery, depending on comorbidities and the choice of anesthesia method. The current development of neuraxial anesthesia techniques and close monitoring devices helps us prevent and detect cognitive impairment early in these patients. In this study, we aimed to investigate the effects of different anesthesia techniques (general anesthesia/spinal anesthesia) applied in orthopedic cases on patient fluid status (pleth variablity index) and regional cerebral oxygenation (NIRS), and their relationship with cognitive dysfunction.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 65 Years 至 —（Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients over the age of 65
- •Patients with an American Society of Anesthesiologists (ASA) score of II-III
- •Patients with a Mini Mental State Examination (MMSE) score of ≥24 on the first day before surgery
排除标准
- •Patients with coagulation disorders
- •Patients with a history of anticoagulant medication use
- •Patients with advanced organ failure
- •Patients with Alzheimer's disease or advanced dementia
- •Patients with allergies to the medications used in the study
- •Mental Retardation
- •Patients with a wound infection at the site of spinal anesthesia
- •Patients with a history of cerebrovascular hemorrhage
- •Patients who did not consent;
研究组 & 干预措施
General Anesthesia
Spinal anesthesia
结局指标
主要结局
Early postoperative period (24th and 48th hours) cognitive dysfunction rate
时间窗: Up to 48 hours after operation
We will assess postoperative cognitive dysfunction.Cognitive function will be evaluated using the MOCA (Montreal Cognitive Assessment) at 24 and 48 hours after surgery.
次要结局
- Pleth Variability Index (PVI, %) to assess intraoperative fluid status(During Surgery)
研究者
Aygul Valiyeva
research assistant
Goztepe Training and Research Hospital