The effect of exercise intensity on biomarkers, and brain function after stroke

Not Applicable

Recruiting

• Conditions: Stroke; Stroke - Ischaemic; Stroke - Haemorrhagic; Physical Medicine / Rehabilitation - Physiotherapy

• Registration Number: ACTRN12623001306606
• Lead Sponsor: Sharon Kramer

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2023-12-14
• Last Update Posted: 8 January 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

Eligibility criteria:
Adult (>21 years of age) stroke survivors
Are eligible for Medicare
Clinically diagnosed with first ever ischaemic/haemorrhagic stroke
Stroke onset between 1 – 12 months ago at enrolment.
Medically stable
No contra-indications to perform moderate to high-intensity exercise.
Able to follow instructions and give written consent

Adult healthy age and sex matched controls (>21 years of age)
Are eligible for Medicare.
Relatively healthy individuals with no contraindications to perform exercise

Exclusion Criteria

Severe cardiac comorbidities such as unstable angina, severe aortic stenosis etc.
Neurological comorbidities other than stroke such as Parkinson’s disease, Multiple Sclerosis etc.
Severe musculoskeletal comorbidities
Severe respiratory comorbidities such as severe COPD, pulmonary fibrosis
Pacemaker implant
Patients or healthy individuals with metal ferromagnetic objects implanted in the head or neck area.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Stress: Salivary Cortisol [Unstimulated saliva samples Immediately after each of the exercise sessions];Inflammatory biomarker: salivary C-reactive protein[Unstimulated Saliva Sample Immediately after each of the exercise sessions]

Secondary Outcome Measures

Name	Time	Method
Corticomotor excitability: resting motor threshold [Transcranial magnetic stimulation Immediately after each of the exercise sessions];Corticomotor excitability: recruitment curve [Transcranial magnetic stimulation Immediately after each of the exercise sessions];Motor map size[Transcranial magnetic stimulation Immediately after each of the exercise sessions]