The effect of acute exercise and fitness level on the aging brain, an investigation with fMRI

Completed

• Conditions: aging; cognitive functioning; 10001474

• Registration Number: NL-OMON43951
• Lead Sponsor: niversitair Medisch Centrum Groningen

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 23 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 100

Inclusion Criteria

Normal (or corrected to normal) vision, healthy, fMRI compatible, no (history of) neurological or psychiatric disorders, fluent in Dutch. Age range: 18-30 or 50-65.

Exclusion Criteria

Smoking. Health issues that could influence the ability to exercise, MR incompatable (posibility of any incompatible metal objects inside the body), alcohol/drug abuse, answering 'yes' to one or more questions on the r-PARQ. MR incompatible, based on the fMRI questionnaire. This includes (but is not limited to) claustrophobia, presence of MR incompatible implants, such as pacemakers or insulin pumps, (suspicion of) pregnancy, tattoo(s) that contain red pigment.

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Main study parameters are functional MRI measurements during two N-back tasks<br /><br>(during the exercise and control session), the effects of fitness level on AB<br /><br>task performance and pupil dilation signal, CBF measurements during two resting<br /><br>states (pre and post exercise).</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>The secundary parameter of the proposed study is the BOLD signal of resting<br /><br>state networks, measured during the resting state scans before and after acute<br /><br>exercise. </p><br>