NCT04123028已完成不适用
The Association Between Blood Eosinophils and Clinical Outcomes of Chronic Obstructive Pulmonary Disease Patients: A Prospective Study
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 145
- 试验地点
- 1
- 主要终点
- Acute worsening of respiratory symptoms
研究概览
简要总结
The association of blood eosinophil as a biomarker for eosinophilic Thai COPD patients, such as COPD exacerbation, hospital admission, lung functions and mortlity.
详细描述
The prospective one year study in Thai COPD patients for the clinical outcomes of COPD compare between eosinophilic and non-eosinophilic which determine by blood eosinophil counts equal or more than 300 cells/microliters. The primary outcomes was COPD exacerbation, the secondary outcomes were lung function, dyspnea and quality of life.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 40 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •diagnosis of COPD by GOLD criteria
排除标准
- •high blood eosinophil from known causes such as systemic corticosteroid use, malignancy, parasitic infection
- •Patients who had previous acute exacerbation within 30-day before study entry
- •Patients who had previous systemic corticosteroids used within 30-day before study entry
结局指标
主要结局
Acute worsening of respiratory symptoms
时间窗: 1 year
acute severe worsening of respiratory symptoms
次要结局
- Physiological outcomes(1 year)
- health related quality of life(1 year)
研究者
Siwasak Juthong
Faculty of Medicine
Prince of Songkla University
研究点 (1)
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