Comparison Of Measured To Predicted Resting Metabolism

Recruiting

• Conditions: Body Weight
• Interventions: Diagnostic Test: Metabolic cart; Diagnostic Test: MedGem; Diagnostic Test: BIA

• Registration Number: NCT06350253
• Lead Sponsor: Ohio University

Brief Summary

The purpose of this study is to compare RMR values from the BIA, predicted equations, and indirect calorimetry.

Detailed Description

Resting metabolic rate (RMR) describes the number of calories a person utilizes while at rest. The gold standard measurement is via inspired and expired air using a metabolic cart. However, researchers have established estimation equations and the use of body composition analysis to predict RMR when a metabolic cart is unavailable. The accuracy of the predicted equations and whole-body bioelectrical impedance (BIA) machines that produce this data is unknown. Therefore, the purpose of this study is to compare RMR values from the BIA, predicted equations, and indirect calorimetry.

Aim 1: to compare measured RMR from indirect calorimetry to values provided by the InBody 770 BIA machine and to established gender and age-appropriate prediction equations.

Aim 2: to compare RMR measured from indirect calorimetry using a metabolic cart (Gold Standard) to the Medgem handheld indirect calorimeter (FDA approved device).

Study Timeline

• Study Start: 2023-03-14
• Study First Submitted: 2024-03-29
• Status Verified: 2024-04
• Study First Submitted QC: 2024-04-04
• Last Update Submitted: 2024-04-04
• Study First Posted: 2024-04-05
• Last Update Posted: 2024-04-05
• Primary Completion: 2024-12-31
• Study Completion: 2025-12-31

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 150

Inclusion Criteria

• Men & women, aged 18-60

Exclusion Criteria

• Have any known or suspected metabolic diseases such as diabetes, thyroid disorder, or high cholesterol
• Have any known or suspected cardiovascular or pulmonary diseases such as hypertension
• Are currently on beta blockers, taking antihypertensives, or antidepressants
• Current smoker or quit less than a year ago
• Unwilling to provide finger stick and urine sample

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
50-60 years old	BIA	-
18-24 years old	MedGem	18-24 years old
50-60 years old	MedGem	-
18-24 years old	Metabolic cart	18-24 years old
24-29 years old	Metabolic cart	-
30-39 years old	BIA	-
40-49 years old	Metabolic cart	-
18-24 years old	BIA	18-24 years old
24-29 years old	BIA	-
30-39 years old	MedGem	-
30-39 years old	Metabolic cart	-
40-49 years old	MedGem	-
24-29 years old	MedGem	-
40-49 years old	BIA	-
50-60 years old	Metabolic cart	-

Primary Outcome Measures

Name	Time	Method
Resting metabolic rate	day 1

Trial Locations

Locations (1)

Ohio University Exercise Physiology Lab; 🇺🇸 Athens, Ohio, United States