Changes in Resting Metabolic Rate Following Orthopedic Surgery

Recruiting

• Conditions: Metabolism; Disorder, Postprocedural; Resting Metabolic Rate; Post Operative Nutrition
• Interventions: Other: Pre-surgical nutrition, hydration, RMR, and body composition assessments; Other: Post-surgical nutrition, hydration, RMR and body composition assessments

• Registration Number: NCT06107959
• Lead Sponsor: University of Kansas Medical Center

Brief Summary

This project is intended to determine the magnitude and duration of RMR changes in patients receiving orthopedic surgery. The result will help to guide postoperative nutrition recommendations in patients receiving orthopedic surgery.

Detailed Description

Surgery produces a catabolic response in the body that shifts metabolism from glucose to fat and protein. Despite no studies examining ACLR, studies of other orthopedic surgeries demonstrate increased postoperative energy expenditure, as well as a shift to beta-oxidation. Additionally, in most patients, these changes reverted to baseline within six weeks, although a subset of patients did not return to baseline until beyond 12 weeks.

This project will improve our understanding of magnitude and duration of RMR changes following orthopedic surgery, and the subsequent perioperative dietary suggestions that should be made to improve patient outcomes. Currently, postoperative dietary suggestions are not surgery nor patient specific. Determining how orthopedic surgery effects RMR will help to personalize perioperative treatment, rehabilitation, and recovery.

Better understanding the change in RMR following orthopedic surgery and implementing more accurate dietary modifications will help to ensure positive outcomes and control of infection following orthopedic surgery.

Study Timeline

• Study Start: 2023-10-10
• Study First Submitted: 2023-10-12
• Study First Submitted QC: 2023-10-24
• Study First Posted: 2023-10-30
• Status Verified: 2024-08
• Last Update Submitted: 2024-08-20
• Last Update Posted: 2024-08-22
• Primary Completion: 2025-06
• Study Completion: 2025-12

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

• Any individual over 15 undergoing an orthopedic surgery.

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Exclusion Criteria

• Pregnant female
• < 15 years old

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Male	Post-surgical nutrition, hydration, RMR and body composition assessments	50 male subjects undergoing orthopedic surgery.
Female	Pre-surgical nutrition, hydration, RMR, and body composition assessments	50 female subjects undergoing orthopedic surgery
Male	Pre-surgical nutrition, hydration, RMR, and body composition assessments	50 male subjects undergoing orthopedic surgery.
Female	Post-surgical nutrition, hydration, RMR and body composition assessments	50 female subjects undergoing orthopedic surgery

Primary Outcome Measures

Name	Time	Method
To observe the amount of time it takes the RMR to return to baseline.	12 weeks	calculation in number of weeks
To determine the magnitude of the change in RMR of patients receiving orthopedic surgery.	12 weeks	RMR = (9.99 X actual weight\*)+ (6.25 X height\*) - (4.92 X age) - 161\*use weight in kilograms (kilogram), height in centimeters (cm).

Trial Locations

Locations (1)

The University of Kansas Medical Center; 🇺🇸 Kansas City, Kansas, United States