A Randomized Double-blinded Placebo-controlled Study to Evaluate the Effect of Collagen Peptide (Collagen Peptan) Supplementation on Muscle and Tendon Damage, Repair, and Functional Capacity During Exercise Training Overload
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Exercise
- Sponsor
- KU Leuven
- Enrollment
- 22
- Locations
- 1
- Primary Endpoint
- Change in maximal isometric knee-extension force of the right leg
- Status
- Completed
- Last Updated
- 3 years ago
Overview
Brief Summary
The aim of the study is to investigate the acute and short-term effects of collagen peptides (Collagen Peptan) on muscle and connective tissue during an eccentric overload training period. Currently, all studies investigating the effects of post-exercise collagen supplementation did this in the absence of whey proteins, which are part of the standard recommendations for post-exercise recovery. The investigators will therefore investigate whether the combined intake of whey proteins and collagen peptides ensures a better recovery of exercise performance and whether it can prevent or reduce symptoms of muscle and tendon overload during a three-week eccentric overload training period (n = 22).
Investigators
Peter Hespel
Principal Investigator
KU Leuven
Eligibility Criteria
Inclusion Criteria
- •Sports participation, including general fitness training, between 2 and 5 hours max per week
- •Body mass index between 18.5 and 25
Exclusion Criteria
- •Any kind of injury/pathology that is a contra-indication to perform high-intensity exercise - Intake of any medication or nutritional supplement that could impact muscle protein synthesis and/or exercise performance during the period of the study
- •Intake of any whey protein, casein of branched-chain amino acid (BCAA) supplements from 1 month prior to the start of the study
- •Blood donation within 3 months prior to the start of the study
- •Current participation in another research trial
- •Any other argument to believe that the subject is unlikely to successfully complete the full study
Outcomes
Primary Outcomes
Change in maximal isometric knee-extension force of the right leg
Time Frame: Pretest - 48 hours after the first training session (day 3 of training intervention) - Posttest (day 22 of training intervention)
Change in maximal isometric knee-extension force (angle = 45°) of the right leg
Change in anteroposterior thickness of the right patellar tendon
Time Frame: Pretest - 48 hours after the first training session (day 3 of training intervention) - Posttest (day 22 of training intervention)
Change in anteroposterior thickness of the right patellar tendon
Change in countermovement jump performance
Time Frame: Pretest - 48 hours after the first training session (day 3 of training intervention) - Posttest (day 22 of training intervention)
Change in jump height when performing a countermovement jump, measured via a force platform
Change in neovascularization of the right patellar tendon
Time Frame: Pretest - 48 hours after the first training session (day 3 of training intervention) - Posttest (day 22 of training intervention)
Neovascularization of the right patellar tendon scored with the Modified Ohberg Score (range 0 - 4; the higher the score, the higher the degree of neovascularization).
Secondary Outcomes
- Change in pain perception at the muscular level (VAS scale)(Training 1 (day 1 of training intervention) - Training 2 (day 3 of training intervention) - Training 8 (day 9 of training intervention) - Training 17 (day 19 of training intervention) - Posttest (day 22 of training intervention))
- Change in the blood concentration of creatine kinase(Pretest - Training 2 (day 3 of training intervention) - Posttest (day 22 of training intervention))
- Change in the blood concentration of Interleukin 6 (IL-6)(Pretest - Training 2 (day 3 of training intervention) - Posttest (day 22 of training intervention))
- Change in the blood concentration of N-terminal propeptide of type I procollagen (P1NP)(Pretest - Training 2 (day 3 of training intervention) - Posttest (day 22 of training intervention))
- Change in pain perception of the patellar tendon of the right leg (VISA-P)(Pretest - Training 1 (day 1 of training intervention) - Training 17 (day 21 of training intervention) - Posttest (day 22 of training intervention))