Effects of Collagen Peptide Supplementation on Muscle and Tendon Damage and Function

Not Applicable

Completed

• Conditions: Exercise; Healthy Male Subjects
• Interventions: Dietary Supplement: whey protein; Dietary Supplement: whey protein + collagen peptide

• Registration Number: NCT05425407
• Lead Sponsor: KU Leuven

Brief Summary

The aim of the study is to investigate the acute and short-term effects of collagen peptides (Collagen Peptan) on muscle and connective tissue during an eccentric overload training period. Currently, all studies investigating the effects of post-exercise collagen supplementation did this in the absence of whey proteins, which are part of the standard recommendations for post-exercise recovery. The investigators will therefore investigate whether the combined intake of whey proteins and collagen peptides ensures a better recovery of exercise performance and whether it can prevent or reduce symptoms of muscle and tendon overload during a three-week eccentric overload training period (n = 22).

Detailed Description

Not available

Study Timeline

• Study Start: 2021-04-12
• Primary Completion: 2021-05-30
• Study Completion: 2021-06-30
• Study First Submitted: 2021-08-03
• Status Verified: 2022-06
• Study First Submitted QC: 2022-06-16
• Last Update Submitted: 2022-06-16
• Study First Posted: 2022-06-21
• Last Update Posted: 2022-06-21

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 22

Inclusion Criteria

• Sports participation, including general fitness training, between 2 and 5 hours max per week
• Body mass index between 18.5 and 25

Exclusion Criteria

• Any kind of injury/pathology that is a contra-indication to perform high-intensity exercise - Intake of any medication or nutritional supplement that could impact muscle protein synthesis and/or exercise performance during the period of the study
• Intake of any whey protein, casein of branched-chain amino acid (BCAA) supplements from 1 month prior to the start of the study
• Blood donation within 3 months prior to the start of the study
• Smoking
• Current participation in another research trial
• Any other argument to believe that the subject is unlikely to successfully complete the full study

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Placebo	whey protein	Only whey protein will be provided
Collagen	whey protein + collagen peptide	A mix of whey protein and collagen peptides will be provided

Primary Outcome Measures

Name	Time	Method
Change in maximal isometric knee-extension force of the right leg	Pretest - 48 hours after the first training session (day 3 of training intervention) - Posttest (day 22 of training intervention)	Change in maximal isometric knee-extension force (angle = 45°) of the right leg
Change in anteroposterior thickness of the right patellar tendon	Pretest - 48 hours after the first training session (day 3 of training intervention) - Posttest (day 22 of training intervention)	Change in anteroposterior thickness of the right patellar tendon
Change in countermovement jump performance	Pretest - 48 hours after the first training session (day 3 of training intervention) - Posttest (day 22 of training intervention)	Change in jump height when performing a countermovement jump, measured via a force platform
Change in neovascularization of the right patellar tendon	Pretest - 48 hours after the first training session (day 3 of training intervention) - Posttest (day 22 of training intervention)	Neovascularization of the right patellar tendon scored with the Modified Ohberg Score (range 0 - 4; the higher the score, the higher the degree of neovascularization).

Secondary Outcome Measures

Name	Time	Method
Change in pain perception at the muscular level (VAS scale)	Training 1 (day 1 of training intervention) - Training 2 (day 3 of training intervention) - Training 8 (day 9 of training intervention) - Training 17 (day 19 of training intervention) - Posttest (day 22 of training intervention)	Change in pain perception at the muscular level of the right leg, measured via the Visual Analogue Scale (range 0 - 10; the higher the score, the higher the pain level)
Change in the blood concentration of creatine kinase	Pretest - Training 2 (day 3 of training intervention) - Posttest (day 22 of training intervention)	Change in blood concentration of creatine kinase (marker of muscle damage)
Change in the blood concentration of Interleukin 6 (IL-6)	Pretest - Training 2 (day 3 of training intervention) - Posttest (day 22 of training intervention)	Change in blood concentration of Interleukin 6 (IL-6; marker of inflammation)
Change in the blood concentration of N-terminal propeptide of type I procollagen (P1NP)	Pretest - Training 2 (day 3 of training intervention) - Posttest (day 22 of training intervention)	Change in blood concentration of N-terminal propeptide of type I procollagen (P1NP; marker of collagen synthesis)
Change in pain perception of the patellar tendon of the right leg (VISA-P)	Pretest - Training 1 (day 1 of training intervention) - Training 17 (day 21 of training intervention) - Posttest (day 22 of training intervention)	Change in pain perception of the patellar tendon of the right leg, measured via the VISA-P questionnaire (range: 0 - 100; the lower the score, the higher the symptoms of patellar tendon overload)

Trial Locations

Locations (1)

Exercise Physiology Research Group; 🇧🇪 Leuven, Vlaams-Brabant, Belgium