Cognitive Training for PTSD: Effects on Cognitive, Emotional, and Brain Function
试验速览
- 阶段
- 不适用
- 入组人数
- 40
- 试验地点
- 2
- 主要终点
- Neural activity in prefrontal regions during cognitive and emotional processing measured by functional magnetic resonance imaging.
研究概览
简要总结
The purpose of this pilot study is to determine the effects of computer-based training in executive functioning compared to word games on cognitive and emotional aspects of combat-related PTSD.
详细描述
Many posttraumatic stress disorder (PTSD) patients either choose not to complete or do not achieve optimal response to current first-line behavioral and pharmacologic treatments. Neurocognitive research points to the potential of novel treatments targeting dorsal prefrontal function and inhibition, attention, and working memory processes. This study investigates effects of computer-based training in executive functions compared to word games on cognitive and emotional aspects of combat-related PTSD. Paper-and-pencil questionnaires, interviews, computer-administered testing, and magnetic resonance imaging will be complete before and after the intervention. Results from this pilot study will provide information concerning feasibility and treatment potential of cognitive training for PTSD.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Investigator)
入排标准
- 年龄范围
- 18 Years 至 45 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •combat veterans who served in Operation Iraqi Freedom, Operation Enduring Freedom, or Operation New Dawn
排除标准
- •enrolled in other active treatment protocols
- •current substance abuse or dependence
- •current suicidal ideation
- •diagnosis of a neurological disorder
- •history of moderate to severe traumatic brain injury
结局指标
主要结局
Neural activity in prefrontal regions during cognitive and emotional processing measured by functional magnetic resonance imaging.
时间窗: change from baseline to after 6 weeks of training
次要结局
- Cognitive functioning as measured by neuropsychological assessment.(change from baseline to after 6 weeks of training)
研究者
Robin Aupperle
Assistant Professor
University of Missouri, Kansas City