Cognitive Training for PTSD: Effects on Cognitive, Emotional, and Brain Function
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Posttraumatic Stress Disorders
- Sponsor
- University of Missouri, Kansas City
- Enrollment
- 40
- Locations
- 1
- Primary Endpoint
- Neural activity in prefrontal regions during cognitive and emotional processing measured by functional magnetic resonance imaging.
- Last Updated
- 11 years ago
Overview
Brief Summary
The purpose of this pilot study is to determine the effects of computer-based training in executive functioning compared to word games on cognitive and emotional aspects of combat-related PTSD.
Detailed Description
Many posttraumatic stress disorder (PTSD) patients either choose not to complete or do not achieve optimal response to current first-line behavioral and pharmacologic treatments. Neurocognitive research points to the potential of novel treatments targeting dorsal prefrontal function and inhibition, attention, and working memory processes. This study investigates effects of computer-based training in executive functions compared to word games on cognitive and emotional aspects of combat-related PTSD. Paper-and-pencil questionnaires, interviews, computer-administered testing, and magnetic resonance imaging will be complete before and after the intervention. Results from this pilot study will provide information concerning feasibility and treatment potential of cognitive training for PTSD.
Investigators
Robin Aupperle
Assistant Professor
University of Missouri, Kansas City
Eligibility Criteria
Inclusion Criteria
- •combat veterans who served in Operation Iraqi Freedom, Operation Enduring Freedom, or Operation New Dawn
Exclusion Criteria
- •enrolled in other active treatment protocols
- •current substance abuse or dependence
- •current suicidal ideation
- •diagnosis of a neurological disorder
- •history of moderate to severe traumatic brain injury
Outcomes
Primary Outcomes
Neural activity in prefrontal regions during cognitive and emotional processing measured by functional magnetic resonance imaging.
Time Frame: change from baseline to after 6 weeks of training
Secondary Outcomes
- Cognitive functioning as measured by neuropsychological assessment.(change from baseline to after 6 weeks of training)