Skip to main content
Clinical Trials/NCT02085512
NCT02085512
Completed
Not Applicable

Prevention of PTSD by Neurocognitive Training of Emotional Regulation

NYU Langone Health1 site in 1 country180 target enrollmentMarch 17, 2017

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Post Traumatic Stress Disorder
Sponsor
NYU Langone Health
Enrollment
180
Locations
1
Primary Endpoint
Amelioration of neurocognitive impairments that are associated with post-traumatic stress disorder
Status
Completed
Last Updated
7 years ago

Overview

Brief Summary

The proposed work will evaluate the ability of neurocognitive retraining of executive functions and emotional regulation to reduce neurocognitive dysfunctions that follow trauma exposure and thereby prevent PTSD. The scientific rationale for this work is the hypothesis that impaired emotional regulation interferes with the expected recovery from the early responses to traumatic events, leading into a chronic disorder. In an initial phase the investigators will recruit 20 recently traumatized participants among trauma survivors admitted to a general hospital emergency room and test the planned intervention's acceptance and right 'dosing'. In the second phase the investigators will enroll 80 recent survivors into a randomized controlled study of the new intervention. The intervention will consist of web-based neurobehavioral training interventions that instill an emotional bias toward positive stimuli, improve emotion recognition and labeling, reduce resistance to emotional distraction, and enhance executive functioning. Control participants will complete web-based video games that do not have emotion-regulatory benefits. Outcome measures will include improvement in neurocognitive functioning and in PTSD symptoms.

Registry
clinicaltrials.gov
Start Date
March 17, 2017
End Date
December 31, 2017
Last Updated
7 years ago
Study Type
Interventional
Study Design
Parallel
Sex
All

Investigators

Responsible Party
Sponsor

Eligibility Criteria

Inclusion Criteria

  • Adult survivors of traumatic events consecutively admitted to a general hospital Emergency Department

Exclusion Criteria

  • Chronic PTSD at the time of the traumatic event. Current and lifetime psychotic or bipolar illness, current substance abuse save alcohol, medical condition precluding participation.

Outcomes

Primary Outcomes

Amelioration of neurocognitive impairments that are associated with post-traumatic stress disorder

Time Frame: Three and nine months after a traumatic event

Impairments in emotional reactivity, emotion regulation, and executive functioning critically contribute to post-trauma psychopathology (including, but not restricted to PTSD). The primary outcome measure of this work are changes (improvements) of these functions at the immediate aftermath of treatment and six months later

Secondary Outcomes

  • Post-traumatic Stress Disorder (PTSD) symptoms(Three and nine months after a traumatic event)

Study Sites (1)

Loading locations...

Similar Trials