Prevention of PTSD by Neurocognitive Training of Emotional Regulation
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Post Traumatic Stress Disorder
- Sponsor
- NYU Langone Health
- Enrollment
- 180
- Locations
- 1
- Primary Endpoint
- Amelioration of neurocognitive impairments that are associated with post-traumatic stress disorder
- Status
- Completed
- Last Updated
- 7 years ago
Overview
Brief Summary
The proposed work will evaluate the ability of neurocognitive retraining of executive functions and emotional regulation to reduce neurocognitive dysfunctions that follow trauma exposure and thereby prevent PTSD. The scientific rationale for this work is the hypothesis that impaired emotional regulation interferes with the expected recovery from the early responses to traumatic events, leading into a chronic disorder. In an initial phase the investigators will recruit 20 recently traumatized participants among trauma survivors admitted to a general hospital emergency room and test the planned intervention's acceptance and right 'dosing'. In the second phase the investigators will enroll 80 recent survivors into a randomized controlled study of the new intervention. The intervention will consist of web-based neurobehavioral training interventions that instill an emotional bias toward positive stimuli, improve emotion recognition and labeling, reduce resistance to emotional distraction, and enhance executive functioning. Control participants will complete web-based video games that do not have emotion-regulatory benefits. Outcome measures will include improvement in neurocognitive functioning and in PTSD symptoms.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Adult survivors of traumatic events consecutively admitted to a general hospital Emergency Department
Exclusion Criteria
- •Chronic PTSD at the time of the traumatic event. Current and lifetime psychotic or bipolar illness, current substance abuse save alcohol, medical condition precluding participation.
Outcomes
Primary Outcomes
Amelioration of neurocognitive impairments that are associated with post-traumatic stress disorder
Time Frame: Three and nine months after a traumatic event
Impairments in emotional reactivity, emotion regulation, and executive functioning critically contribute to post-trauma psychopathology (including, but not restricted to PTSD). The primary outcome measure of this work are changes (improvements) of these functions at the immediate aftermath of treatment and six months later
Secondary Outcomes
- Post-traumatic Stress Disorder (PTSD) symptoms(Three and nine months after a traumatic event)