Muscle relaxation properties in myopathies with positive muscle phenomena: a study using transcranial magnetic stimulatio

Completed

• Conditions: muscle disorder; Myopathies; 10028396; 10028302

• Registration Number: NL-OMON43031
• Lead Sponsor: Radboud Universitair Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 23 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 85

Inclusion Criteria

Diagnosis of one of the following myopathies:
- Nemaline myopathy type 6 (NEM6)
- Ryanodine receptor type 1 related myopathy (RYR1)
- Myotonic dystrophy type 2 (DM2)
- Mitochondrial myopathy
- McArdle disease
- Facioscapulohumeral muscular dystrophy (FSHD)

Exclusion Criteria

Age <18
Pregnancy
Serious head trauma or brain surgery
Large or ferromagnetic metal parts in the head
Implanted cardiac pacemaker or neurostimulator
Epilepsy, convulsion or seizure
Use of medication that can influence muscle relaxation or cortical excitability

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Peak relaxation rate normalized for force<br /><br>Relaxation times: 0.9RT, 0.75RT, 0.50RT, 0.25RT<br /><br>E.g. 0.50RT is the time needed for force to drop from 100% to 50% of maximal<br /><br>force </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Maximal force of fingerflexors</p><br>