Canadian Cohort on the Origin and Progression of Airway Disease: Physiology Platform

Completed

• Conditions: Smoking; COPD

• Registration Number: NCT02153684
• Lead Sponsor: Dr. Denis O'Donnell

Brief Summary

The Canadian Respiratory Research Network (CRRN) has recently been established to study the origins and evolution of airways disease in the population. The CRRN is funded by the Institute of Cardio-respiratory Health (ICRH), an institute of the CIHR. The Physiology platform will support the other CRRN platforms (biology, imaging, population health, knowledge transfer) by providing a comprehensive characterization of the nature and extent of physiological impairment of respiratory function in smokers at risk for airways disease and in those with early or mild airway obstruction. The planned studies of the physiology group (core sites located at Queen's University, University of British Columbia and McGill University) will initially focus on smoking-related lung injury in those at risk for COPD and in those meeting spirometric criteria for mild airway obstruction, with or without respiratory symptoms. The primary aim of this initial study is to identify and validate sensitive test(s) of peripheral airway dysfunction that may qualify as physiological biomarkers for use in future CRRN studies.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2014-05-30
• Study First Submitted QC: 2014-06-02
• Study First Posted: 2014-06-03
• Study Start: 2015-03
• Primary Completion: 2022-09-30
• Study Completion: 2022-09-30
• Status Verified: 2024-04
• Last Update Submitted: 2024-04-01
• Last Update Posted: 2024-04-03

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 99

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Small airway function	1 day (Time of visit)	There is no single measurement of small airway function since this study is evaluating which measurements, among a list of conventional and experimental physiological parameters, best characterize the nature and extent of impairment of respiratory function in the smoking study groups and which of these parameters best predict clinical outcome (i.e., dyspnea, exercise capacity, ventilatory capacity, health status). Assessments will include: spirometry, closing volume, impulse oscillometry, frequency dependence of dynamic lung compliance, plethysmographic lung volumes and metronome-paced dynamic hyperinflation.

Secondary Outcome Measures

Name	Time	Method
Cardiopulmonary exercise test	1 day (Time of visit)	Includes measurements of exertional dyspnea (intensity and quality), peak exercise capacity (peak oxygen uptake \[VO2\]) and ventilatory responses (ventilation, pulmonary gas exchange, breathing pattern, operating lung volumes and tidal flow-volume loops) during symptom-limited incremental cardiopulmonary cycle exercise testing.
Clinical outcome	1 day (Time of visit)	Includes questionnaires regarding chronic activity-related dyspnea, respiratory symptoms, health status and physical activity.

Trial Locations

Locations (3)

McGill University; 🇨🇦 Montreal, Quebec, Canada

University of British Columbia; 🇨🇦 Vancouver, British Columbia, Canada

Queen's University and Kingston General Hospital; 🇨🇦 Kingston, Ontario, Canada