Effect of Shift Work on Post Prandial Dysmetabolism

Not Applicable

• Conditions: This study aims to explore the impact of an imposed de-synchronisation between circadian rhythms, sleep cycles and eating patterns - as would occur during a rotation between day and night work, on postprandial dysmetabolism.; Metabolic and Endocrine - Normal metabolism and endocrine development and function; Cardiovascular - Normal development and function of the cardiovascular system

• Registration Number: ACTRN12612000492853
• Lead Sponsor: niversity of Sydney

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2012-05-07
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: ot yet recruiting
• Sex: All
• Target Recruitment: 5

Inclusion Criteria

Healthy volunteers, with no shift work experience

Exclusion Criteria

Hypertriglycerdemia (TAG > 4mmol/dl), Impaired fasting glucose (>5.6 mmol/dL), Current shift worker, Moderate or worse OSA (AHI>15) or treated OSA, history of cardiovascular, renal or metabolic disease including stroke, coronary heart disease, kidney disease and diabetes (Type 1&2), other co-morbid sleep conditions (insomnia, sleep phase syndromes, narcolepsy etc) neurological or psychiatric disease that the investigators consider will alter normal sleep patterns.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Blood samples will be taken from an intravenous catheter to determine triglycerides, Free Fatty Acids, Glucose, Insulin and Cortisol levels[Every hour on Day 1 and 3 of each shift];Blood glucose levels will also be monitored by a Continuous glucose monitoring device[Readings will be recorded every hour for all 3 days of each shift.]

Secondary Outcome Measures

Name	Time	Method
eurocognitive performance on the AusEd driving simulator[Before and after every simulated work shift (for both the night and day shift conditions)]