Development of Maternal Voice Recognition in Preterm Neonates
- Conditions
- Infant, Premature
- Interventions
- Device: electroencephalogram (HR-EEG)Device: Near Infra Red Spectroscopy (NIRS)
- Registration Number
- NCT02818595
- Lead Sponsor
- Centre Hospitalier Universitaire, Amiens
- Brief Summary
Many cognitive functions in humans are based on asymmetrical brain networks. For example, in most adults, the language is essentially processed by the left hemisphere, while other auditory functions, such as voice recognition, tend to be processed by the right hemisphere. Many studies, especially those conducted by Ghislaine Dehaene's team, have demonstrated the presence of anatomical and functional asymmetries by the first months of life. What are the causes of these asymmetries? How do they develop? Are they necessary for functioning or effective learning?
This study, conducted in collaboration with the Compiègne applied mathematics team (Abdelatif El Badia) and the INSERM team (Ghislaine Dehaene), is designed to determine the stage of development at which hemispheric dominance for voice recognition is first observed and to identify the brain structure involved in preterm neonates whose sound environment is usually very different from that of the foetus. The impact of this environment on the infant's brain development and early learning will be evaluated.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 22
- The distribution of children in the different groups of infants included in the study will be validated at the time of the acquisitions.
- Normal group of children: A child meets the age criteria and without ductus arteriosus persistence ultrasound or detectable neurological disorders after clinical, neurophysiological and radiological (ETF, Scanner, MRI).
- Group of children meet the age criteria and with cerebral neurological pathology detectable after clinical, neurophysiological and radiological (ETF, Scanner, MRI).
About history:
- All children with severe congenital malformation
Regarding the study period;
- Any refusal of a parent
- Children with severe impairment of the general condition and vital functions
- Children with dermatitis of the face or scalp
- Children treated with ventilation High Frequency (HFO)
- Presence of intravenous access on the scalp (preventing the realization of the ETF, EEG and NIRS
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Normal children electroencephalogram (HR-EEG) Every child meet the age criteria and without ductus arteriosus persistence ultrasound or detectable neurological disorders after clinical, neurophysiological and radiological Abnormal children Near Infra Red Spectroscopy (NIRS) Every child meet the criteria of age and having a detectable neurological disease after clinical, neurophysiological and radiological as intraventricular hemorrhage . Abnormal children electroencephalogram (HR-EEG) Every child meet the criteria of age and having a detectable neurological disease after clinical, neurophysiological and radiological as intraventricular hemorrhage . Normal children Near Infra Red Spectroscopy (NIRS) Every child meet the age criteria and without ductus arteriosus persistence ultrasound or detectable neurological disorders after clinical, neurophysiological and radiological
- Primary Outcome Measures
Name Time Method The difference in amplitude 10 weeks The difference in amplitude of the electrical hemodynamic responses to stimuli depending on the conditions, which corresponds to the evoked potential mismatch Response
The difference in latency 10 weeks The difference in latency of the electrical hemodynamic responses to stimuli depending on the conditions, which corresponds to the evoked potential mismatch Response
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
CHU Amiens
🇫🇷Amiens, France