Speech prosody and psychomotor skills as correlate – personalized medicine in major depressio

• Conditions: F32.2; F32.1; Severe depressive episode without psychotic symptoms; Moderate depressive episode

• Registration Number: DRKS00024594
• Lead Sponsor: niversitätsklinikum Freiburg, Klinik für Psychiatrie und Psychotherapie, Abteilung für Interventionelle Biologische Psychiatrie

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2021-02-19
• Study Completion: 2023-08-03
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Recruiting stopped after recruiting started
• Sex: All
• Target Recruitment: 3

Inclusion Criteria

Patients:
- Chronic or recurrent treatment-resistant depression, pre-diagnosed and documented (uni- or bipolar, currently depressed)
- Capable to give written informed consent

Healthy controls:
- Capable to give written informed consent

Exclusion Criteria

Patients:
- non-affective psychotic disorder, currently or in the past
- Present or unstable substance abuse (except nicotine)

Healthy controls:
- Current psychotherapy or psychiatric treatment
- Current psychiatric disorder
- Past psychotic disorder
- Substance abuse (except nicotine)
- Substantial somatic illness

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Prosody parameters of speech (speech rate, intonation, loudness, duration of silence) and psychomotor performance (tapping accuracy, tapping velocity, precision, sliding velocity) will be assessed up to five times automatically. To this aim two different types of tasks have to be performed on a tablet pc.

Secondary Outcome Measures

Name	Time	Method
Severity of depression (HAMD-28, MADRS)