anguage, speech and motor function in mild cognitive impairment due to AD and Alzheimer*s disease

• Conditions: neurodegeneratieve aandoening; Aandoening: Alzheimer's disease. Synoniemen: Alzheimer / Dementia

• Registration Number: NL-OMON56613
• Lead Sponsor: Hanzehogeschool Groningen

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 9 April 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 208

Inclusion Criteria

In order to be eligible to participate in this study:
A subject with MCI with a likelihood of underlying AD pathophysiology must meet
the following criteria:
* Established diagnosis of MCI due to AD with a likelihood according to NIA-AA
criteria (Albert et al., 2011).
* A score of stage three on the Global Deterioration Scale (GDS) (Reisberg et
al., 1982).

A subject with AD must meet the following criteria:
* Established diagnosis of AD (amnestic or non-amnestic) or etiologically mixed
presentation of AD according to DSM-5 (American Psychiatric Association, 2013)
or NINCDS-ARDRA criteria (Jack et al., 2018; McKann et al., 2011).
* The following scores on the Global Deterioration Scale (GDS): four for mild
AD, five for moderate AD (Reisberg et al., 1982).

All subjects of the control group must meet the following criteria:
* A score of stage one or two on the Global Deterioration Scale (GDS) (Reisberg
et al., 1982).
* They are age-matched with the MCI due to AD or AD patients included in the
study.

All subjects must meet the following criteria:
* First language is Dutch and/or Frisian.
* Able to walk independently with or without walking aid.
* Able to squeeze with each hand.

Exclusion Criteria

A subject with MCI due to AD or AD who meets the following criteria will be
excluded from participation in this study:
* Having a neurological or neurodegenerative disease or disorder that may be
contributing to cognitive impairment above and beyond that caused by AD or
mixed AD; Down*s syndrome, other subtypes of dementia, autism spectrum disorder.
* Having an established diagnosis of a psychiatric disorder, e.g.
schizophrenia, depression.

All subjects in the control group who meets following criteria will be excluded
from participation in this study:
* Suffers from a neurological, neurodegenerative or psychiatric disease or
disorder.

All subjects in any group who meet any of the following criteria will be
excluded from participation in this study:
* Hearing loss (with or without hearing aid) that affects communication.
* Vision loss (with or without glasses or lenses) that affects communication.
* History of language problems, speech problems or dyslexia.
* Suffers from additional disorders or diseases which may limit gait, hand grip
strength, language and/or speech.
* Medication use that influence gait, hand grip strength, speech or language
performance at time of testing.
* Being terminally ill (i.e., life expectancy < 2 weeks according to the
attending physician).

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Characteristics of language, speech and motor functions in MCI due to AD, mild<br /><br>AD and moderate AD</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Association between language and motor functions in MCI due to AD, mild AD and<br /><br>moderate AD</p><br>