Subjective cognitive impairment and mild cognitive impairment: a sign of incipient Alzheimer*s disease? * A longitudinal study of functional and structural brain changes in healthy older adults with and without cognitive complaints.

Recruiting

• Conditions: Subjective cognitive impairment; 10029299; memory complaints; 10012272

• Registration Number: NL-OMON40552
• Lead Sponsor: eids Universitair Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 29 April 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 80

Inclusion Criteria

Healthy adults aged 40-90 with or without memory complaints. Adults with SCI must have undergone a formal medical assessment that concluded that no objective cognitive impairment was apparent. Adults with MCI must have undergone a formal medical assessment that concluded that impairment in memory and intraindividual change was apparent, but no evidence of a significant impairment in social or occupational functioning.

Exclusion Criteria

Left-handedness; any significant diagnosed medical, neurological or psychiatric illness; a history of brain damage; or the use of psychoactive medication will exclude volunteers from participating. Participants will also disqualify if they have any MRI contraindications such as: implanted electrical device (e.g., cardiac pacemaker) or metallic clip (e.g., aneurysm clip). We will also warn participants that some individuals experience claustrophobia in the scanner. We will seek equal representations of men and women.

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>1) MRI (resting state fMRI, task related fMRI, DWI and structural MRI), 2)<br /><br>cognitive parameters, 3) APOE * genotype.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>not applicable</p><br>