Subjective Cognitive Impairment Cohort, a focus on the earliest changes leading to Alzheimer*s disease.
Recruiting
- Conditions
- Preclinical Alzheimer's diseasefirst symptoms of Alzheimer's disease10012272
- Registration Number
- NL-OMON53088
- Lead Sponsor
- Amsterdam University Medical Center, VU Universty Medical Center
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 500
Inclusion Criteria
- Label of subjective memory complaints (i.e. no diagnosis of dementia, mild
cognitive impairment, psychiatric or neurological disorder explaining cognitive
complaints).
- Signed informed consent projects P2005_160, P2000_211, P2016_061 or P2016_409.
- Age * 45 year.
Exclusion Criteria
- Insufficient knowledge of Dutch language.
- Major psychiatric disorder, such as psychosis, schizophrenia, severe
personality disorder or depression with vital signs, abuse of alcohol or other
substances.
- Neurological disorder such as Parkinson*s disease, symptomatic stroke, mental
retardation.
- Acquired Immune Deficiency Syndrome (AIDS) or Human Immunodeficiency Virus
(HIV).
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Clinical progression, i.e. progression to a clinical diagnosis of MCI or<br /><br>dementia. </p><br>
- Secondary Outcome Measures
Name Time Method <p>- Decline in cognitive functioning on neuropsychological testing (i.e. memory,<br /><br>language, visuospatial functioning, attention, executive functioning etc).<br /><br>- Decline in daily functioning as measured using the Amsterdam IADL<br /><br>questionnaire<br /><br>- Amyloid-positivity (as measured using CSF biomarkers and/or amyloid-PET) as<br /><br>an endophenotype for AD. </p><br>