Building vascular cognitive impairment cohort for study of Subcortical vascular dementia and Alzheimer's disease dementia
- Conditions
- Mental and behavioural disorders
- Registration Number
- KCT0005428
- Lead Sponsor
- Gachon University Gil Medical Center
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 360
Cognitively Normal (CN)
•Normal cognition will be defined according to neuropsychological testing, which didn't fall within 1.5 SD, and Clinical Dementia Rating (CDR) was 0 .
- Mild cognitive impairment (MCI):
•CDR was 0.5
•Subjects were not be clinically diagnosed with dementia according to Diagnostic and Statistical Manual of Mental Disorders, 4th. Edition, Text-revision (DSM-IV-TR) criteria.
- Dementia (AD and SVaD)
- Alzheimer's disease (AD)
•CDR = 0.5
•subjects were diagnosed with dementia according to DSM-IV-TR.
•subjects were diagnosed with probable AD or possible AD according to the National Institute of Neurological and Communicative Disorders and Stroke and the Alzheimer’s Disease and Related Disorders Association (NINCDS-ADRDA) criteria.
- Subcortical vascular dementia (SVaD)
•CDR = 0.5
•Subjects were diagnosed with vascular dementia according to DSM-IV-TR.
•In FLAIR images, whitematter hyperintensity was more than moderate according to the modified Fazeka’s scale.
- Subjects who do not meet the inclusion criteria.
- Subjects who have history of any significant neurological disease other than AD or VD , such as traumatic brain injury, Parkinson's disease, Huntington's disease, motor neuron disease, or multiple sclerosis.
- Subjects who have history of brain tumor, normal presure hydrocephalus, encephalitis, or metabolic encephalopathy.
- Subjects who have history of a massive stroke in cerebrum, brain strem or cerebellum.
- Subjects who have history of psychiatric disorder.
- Subjects unable to undergo MRI or PET scanning.
- Pregnent or reast feeding women.
Study & Design
- Study Type
- Observational Study
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Analysis of Cognitive Function and Brain Structural Changes Between Groups During Follow-up Assessments(Linear mixed model), and Evaluation of the Imp act on Cognitive Impairment and Brain Atrophy(Cox proportional hazard mode l)
- Secondary Outcome Measures
Name Time Method Analysis of the Impact on Cognitive Function and Brain Structural Changes Bet ween Groups - Using Structural Equation Model and Relative Importance Meth od