NCT01962155已完成不适用
Prospective Stuy in Evaluating Hepatic Fibrosis Related to Hepatitis B Virus
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 1,841
- 试验地点
- 30
- 主要终点
- determine whether a non-invasive test or a combination of non invasive tests may be used to accurately evaluate liver fibrosis in patients with chronic hepatitis B
研究概览
简要总结
The aim of our prospective study is to construct and validate a non-invasive model consisting biochemical markers, FibroScan, and radiological parameters for evaluating liver fibrosis caused by hepatitis B virus in mainland China.
详细描述
Up to Oct, 2015,total of 1800 patients with chronic HBV infection were enrolled. Paired blood and liver biopsy samples were collected. Blood samples stored at -80 degree Celsius. Liver biopsy samples were judged by three pathology experts.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •HBsAg positive for at least 6 months
- •agree to have liver biopsy
- •Male or female aged 18 to 65 years old
排除标准
- •Patients with alcoholic liver disease, autoimmune liver disease, heretic liver disease, drug induced liver disease,nonalcoholic liver disease or other chronic liver disease
- •platelet count < 80000/L
- •prothrombin activity ≤ 60%
- •patients with any disease or condition which the investigator or treating physician feels would interfere with the trial or the safety of the subject
结局指标
主要结局
determine whether a non-invasive test or a combination of non invasive tests may be used to accurately evaluate liver fibrosis in patients with chronic hepatitis B
时间窗: singular evaluation at the time of liver biopsy
次要结局
未报告次要终点
研究者
Guiqiang Wang
MD
Peking University First Hospital
研究点 (30)
Loading locations...
相似试验
Unknown
不适用
A Study in Reversing Hepatic Fibrosis or Cirrhosis Related to Hepatitis B Virus and Finding BiomarkersLiver FibrosisHepatitis BNCT03568578Peking University First Hospital450
已完成
不适用
Prospective Study In Noninvasive Evaluation of Hepatic Fibrosis in Chronic Hepatitis BChronic Hepatitis BNCT01679769Peking University First Hospital818
Unknown
不适用
Non-invasive Diagnostic Model of Liver Fibrosis Associated With NAFLD and Prediction of PrognosisNon-alcoholic Fatty Liver DiseaseNCT03842748Beijing Municipal Administration of Hospitals300
已完成
不适用
Effects of Hepatic Fibrosis on Hepatic Steatosis Using the Ultrasound Attenuation Imaging in Chronic Hepatitis BHepatic SteatosisChronic Hepatitis bHepatic FibrosisNCT05871749So Yeon Kim120
已完成
不适用
Development of a Novel Biomarker for Liver FibrosisLiver FibrosisNCT02348814University of California, Los Angeles25