Efficacy of fluoroscopic and ultrasound guided genicular nerve ablation for chronic knee osteoarthritis

Not Applicable

• Conditions: Osteoarthitic knee pain; osteoarthritic knee, radiofrequency ablasion, genicular nerve, conservative treatment, fluoroscopic, ultrasound

• Registration Number: TCTR20190702003
• Lead Sponsor: Faculty of medicine, Siriraj hospital funding

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2019-07-02
• Study Completion: 2023-03-31
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: nknown
• Sex: All
• Target Recruitment: 170

Inclusion Criteria

1. Age >50 years with knee osteoarthritis including the following criteria:
- pain score >=4 from osteoarthritis
- malalignment of knee
- plain film of the knee showed stage 3 or 4 of knee osteoarthritis
- not proceed to surgery within 1 year
2. Failed conservative treatment over 2 months (quadricep exercise, weight control, life style modification, analgesic medications)

Exclusion Criteria

1. Coagulopathy or bleeding disorder, systemic infection, infection around knee
2. Currently receiving the treatment of intraarticular visco-supplement injection
3. Connective tissue disease that involved skin around knee joints
4. On pacemaker
5. Unknown history of previous treatment
6. Uncontrolled psychiatric diseases (schizhrophrenia, major depressive disorder, generalized anxiety disorder)
7. Negative diagnostic block

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
pain score 3 month after an intervention numerical rating scale,pain score 1 month after an intervention numerical rating scale

Secondary Outcome Measures

Name	Time	Method
pain score 1 years numerical rating scale,Function of knee 4, 12, 26, 38, 52 weeks Thai Oxford Knee score (Thai OKS), Thai KOOS short form (Thai KOOS SF), Time up and go test (TUG tes,analgesic drug consumption 4, 12, 26, 38, 52 weeks Baseline pain medication, Rescue pain medication ,range of motion of knee 4, 12, 26, 38, 52 weeks Range of motion (ROM) of the knee,quality of life 4, 12, 26, 38, 52 weeks EuroQoL 5D-5L (Thai version),Inflammation process 0, 4, 12 weeks ESR and hs-CRP blood level,safety of genicular nerve ablation 0, 4, 12, 26, 38, 52 weeks Side effects and complications, Fall evaluation