MedPath

Predictors of Bleeding Evaluation in Adult Hematologic Patients with Bleeding Tendencies

Recruiting
Conditions
von Willebrand disease, platelet function disorders, coagulation factor deficiencies, fibrinolysis disorders, bleeding of unknown cause
Registration Number
NL-OMON27868
Lead Sponsor
MUMC+
Brief Summary

Not available

Detailed Description

Not available

Recruitment & Eligibility

Status
Recruiting
Sex
Not specified
Target Recruitment
300
Inclusion Criteria

Age > 18 years;
Signed informed consent;
Patients with (suspected) bleeding tendency.

Exclusion Criteria

Pregnancy (or lactating);
Active bleeding due to medical interventions or surgical/obstetrical causes.
The use of medication which may interfere with diagnostic tests.

Study & Design

Study Type
Observational non invasive
Study Design
Not specified
Primary Outcome Measures
NameTimeMethod
To assess the diagnostic parameters: sensitivity, specificity, negative predictive value, positive predictive value, likelihood ratio of the experimental haemostatic tests by comparing them to our standard diagnostic algorithm (MUMC protocol) as gold standard.
Secondary Outcome Measures
NameTimeMethod
umber of patients with discrepant results in different aggregations assays (multiplate vs. LTA);<br>Discrepant results between PFA and vWF antigen/activity;<br>Optimizing cost-effectiveness in diagnostic strategies.
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