Oncologic and Obstetric Outcomes After Conization for Uterine Cervical Lesion: A Cohort Study
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 10,000
- 试验地点
- 1
- 主要终点
- The cumulative incidences of precancerous lesions or cancers
研究概览
简要总结
This study is to investigate the oncologic and obstetric outcomes in patients with conization for uterine cervical lesions from January 1, 2000 to January 1, 2019 in Peking Union Medical College Hospital.
The primary objectives consist of following:
- The cumulative incidences of precancerous lesions and cancers of lower genital tract in patients who accepted conization for high grade intraepithelial neoplasia (HSIL), carcinoma in situ and stage IA1 cancer (FIGO 2009)
- The cumulative pregnancy rates in patients sparing the fertility
The secondary objectives consist of following:
- The effects of surgical protocols (modified Sturmdorf method and "8" figure suture) and energy equipment (cold knife and monopolar electrical cautery) on the oncologic and obstetric outcomes, and on the histological components.
- A full description of histological components of the conization specimens
- The cytological and virus outcomes after conization, based on the thin prep liquid-based cytology test (TCT) and high-risk human papillomavirus (HPV) testing
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Accepting conization in the study center
- •Aged 18 years or older
排除标准
- •Not meeting any of the inclusion criteria
结局指标
主要结局
The cumulative incidences of precancerous lesions or cancers
时间窗: Five years
The cumulative incidences of precancerous lesions and cancers of lower genital track in patients who accepted conization for high grade intraepithelial neoplasia (HSIL), carcinoma in situ and stage IA1 cancer (FIGO 2009)
The cumulative pregnancy rates
时间窗: Five years
The cumulative pregnancy rates in patients sparing the fertility
次要结局
- The cumulative live birth rates(Five years)
- The virus outcomes after conization(Five years)
- The cumulative pregnancy loss rates(Five years)
- The cytological results after conization(Five years)
研究者
Lei Li
Professor
Peking Union Medical College Hospital