Oncologic and Obstetric Outcomes After Conization for Uterine Cervical Lesion: A Cohort Study
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Precancerous Lesions
- Sponsor
- Lei Li
- Enrollment
- 10000
- Locations
- 1
- Primary Endpoint
- The cumulative incidences of precancerous lesions or cancers
- Last Updated
- 6 years ago
Overview
Brief Summary
This study is to investigate the oncologic and obstetric outcomes in patients with conization for uterine cervical lesions from January 1, 2000 to January 1, 2019 in Peking Union Medical College Hospital.
The primary objectives consist of following:
- The cumulative incidences of precancerous lesions and cancers of lower genital tract in patients who accepted conization for high grade intraepithelial neoplasia (HSIL), carcinoma in situ and stage IA1 cancer (FIGO 2009)
- The cumulative pregnancy rates in patients sparing the fertility
The secondary objectives consist of following:
- The effects of surgical protocols (modified Sturmdorf method and "8" figure suture) and energy equipment (cold knife and monopolar electrical cautery) on the oncologic and obstetric outcomes, and on the histological components.
- A full description of histological components of the conization specimens
- The cytological and virus outcomes after conization, based on the thin prep liquid-based cytology test (TCT) and high-risk human papillomavirus (HPV) testing
Investigators
Lei Li
Professor
Peking Union Medical College Hospital
Eligibility Criteria
Inclusion Criteria
- •Accepting conization in the study center
- •Aged 18 years or older
Exclusion Criteria
- •Not meeting any of the inclusion criteria
Outcomes
Primary Outcomes
The cumulative incidences of precancerous lesions or cancers
Time Frame: Five years
The cumulative incidences of precancerous lesions and cancers of lower genital track in patients who accepted conization for high grade intraepithelial neoplasia (HSIL), carcinoma in situ and stage IA1 cancer (FIGO 2009)
The cumulative pregnancy rates
Time Frame: Five years
The cumulative pregnancy rates in patients sparing the fertility
Secondary Outcomes
- The cumulative live birth rates(Five years)
- The virus outcomes after conization(Five years)
- The cumulative pregnancy loss rates(Five years)
- The cytological results after conization(Five years)