The effect of clomiphen citrate with flutamid in PCOS patients
- Conditions
- PCOS patients with clomid failure.Polycystic ovarian syndrome
- Registration Number
- IRCT201105081141N10
- Lead Sponsor
- Reproductive medicine research center, Royan Institute, ACECR
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- Female
- Target Recruitment
- 96
Inclusion: Age under 37 years; PCOS diagnosed by the Rotterdam and legro and lanham criteria, by two of the following three features : 1) oligo or an ovulation, 2) clinical and or biochemical signs of hyper androgenism, or 3) polycystic ovaries; previously documented dominant follicle or follicles (R12mm mean diameter) on trans vaginal ultrasound follicular monitoring; normal uterine cavity and patent tubes by either hyserosalpin go gram or laparoscopy and hysteroscopy; normal fasting glucose; normal serum prolactione and thyroid stimulating hormone, estradiol, LH, testestron, normal semen analysis by world health organization criteria. Exclusion: Discontent of athending the study and being allergic to the intended drugs (Flutamid or clomiphene citrate); hyper prolactinemia; thyroid dysfunction; age over 37; and BMI >30.
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Improving ovulation, number of dominant follicles. Timepoint: number of dimnant follicles>18 mm in the mid cycle. Method of measurement: sonography.
- Secondary Outcome Measures
Name Time Method Regulating of cycles, during of stimulation. Timepoint: observation of follicles by sonography. Method of measurement: sonography and measurement of progestron in 19 th and 21 th cycle.