Comparison of the Cardiovascular Benefits of Resistance, Aerobic, and Combined Exercise
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 406
- 试验地点
- 2
- 主要终点
- Change in composite cardiovascular disease risk score (z-score)
研究概览
简要总结
As the leading cause of death, cardiovascular disease (CVD) accounts for about one-third of U.S. mortality. Physical inactivity, one of the main CVD risk factors, causes 6% of coronary heart disease worldwide. The American Heart Association has identified cardiovascular health behaviors including smoking, obesity, diet, and aerobic exercise; however, resistance exercise was not included due to the limited evidence of its efficacy. Comparatively, the cardiovascular benefits of aerobic training have been well-documented whereas the independent and additive benefits of resistance training on cardiovascular health have not been established. Thus, this project is aimed to answer one of the most common questions about exercise and health:"What type or combination of exercise is most effective for CVD prevention?" This project will significantly contribute to developing more effective CVD prevention approaches, advancing more comprehensive physical activity guidelines, and providing important insights and novel opportunities for the future science of physical activity and health.
详细描述
Participants will be randomly assigned to aerobic exercise, resistance exercise, combined aerobic and resistance exercise, or a no exercise control group for 1 year. Participants in all four groups will receive healthy diet and lifestyle education sessions and will track their daily steps, body weights, and food intake throughout the 1-year intervention. They will also complete baseline, 6-month, and 12-month physical examinations, which will include assessments of blood pressure, blood lipids, body composition, and aerobic and muscular fitness.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 35 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Non-smoker
- •Systolic/diastolic blood pressure of 120-139/80-89 mmHg (without taking any anti-hypertensive medication)
- •Overweight or obese: body mass index of 25-40 kg/m2; Asian 23-40 kg/m2
- •Inactive: less than 150 min/week of exercise over the past 3 months
- •Capable of performing the required exercise training
排除标准
- •Unstable coronary heart disease or heart failure
- •Uncontrolled arrhythmias or severe aortic stenosis
- •Acute myocarditis, endocarditis, or pericarditis
- •Cancer, requiring treatment in the past 5 years
- •Autoimmune diseases, affecting the immune system
- •Plans to be away/travel for greater than 4 weeks in the next year
- •Pregnancy/anticipated pregnancy during the study
- •Other medical condition that is life-threatening or can interfere with or be aggravated by the exercise training
结局指标
主要结局
Change in composite cardiovascular disease risk score (z-score)
时间窗: 12 months
The primary outcome is the change from baseline in the composite cardiovascular disease risk score (z-score) calculated using resting blood pressure, low-density lipoprotein cholesterol, fasting glucose, and percent body fat. Each risk factor will be individually standardized and expressed as sex-specific z-score by using the formula = (value - mean)/standard deviation for each participant.
次要结局
未报告次要终点
研究者
Duck-chul Lee
Assistant Professor
Iowa State University