Comparison of nalbuphine and buprenorphine as adjuvants to ropivacaine in interscalenebrachial plexus block

Phase 2

Not yet recruiting

• Conditions: Fracture of clavicle, (2) ICD-10 Condition: S424||Fracture of lower end of humerus, (3) ICD-10 Condition: S423||Fracture of shaft of humerus, (4) ICD-10 Condition: S422||Fracture of upper end of humerus,

• Registration Number: CTRI/2021/03/031818
• Lead Sponsor: Dr Anitha A

Brief Summary

To compare the effect of Nalbuphine and Buprenorphine as an adjuvant to Ropivacaine in

ultrasound guided interscalene brachial plexus block with respect to



1. To assess the onset and duration of sensory and motor blockade.



2. To assess duration of analgesia.

Detailed Description

Not available

Study Timeline

• Last Update Posted: 2021-07-03
• Study Start: 2021-11-03

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

American Society of Anaesthesiologists (ASA) physical status I and II scheduled for upper limb surgery.

Exclusion Criteria

• Any neurological deficit, peripheral neuropathies, myopathies or chronic pain in the operative limb.
• History of anaphylaxis to local anaesthetics or known allergy to any of the study drugs to be used.
• Any history of bleeding diathesis or coagulation abnormalities.
• Any skin infection or local disease at the needle insertion site.
• BMI more than 35kg/sq-m, failure to achieve adequate block within 30 mins of administration.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Duration of sensory and motor block.	Time to onset of sensory and motor block. | Duration of sensory and motor block. | Duration of analgesia
Time to onset of sensory and motor block.	Time to onset of sensory and motor block. | Duration of sensory and motor block. | Duration of analgesia
Duration of analgesia	Time to onset of sensory and motor block. | Duration of sensory and motor block. | Duration of analgesia

Secondary Outcome Measures

Name	Time	Method
Pain scores	Adverse effects- Hypotension, Bradycardia,

Trial Locations

Locations (1)

Kempagowda Institute of medical science; 🇮🇳 Bangalore, KARNATAKA, India

Kempagowda Institute of medical science

🇮🇳Bangalore, KARNATAKA, India

Dr Anitha A

Principal investigator

9842444924

anithaads91@gmail.com