A Study to Establish a Genetic Registry for the Cardiovascular Diseases in The Asian Population

Title: Asian Genetic Registry for Cardiovascular Diseases (AGRC)

Study Type: Prospective Observational Study (Registry)

Background:

Cardiovascular diseases (CVDs) are the leading cause of morbidity and mortality globally, with genetic factors playing a significant role in disease susceptibility, progression, and response to treatment. South Asian populations are disproportionately affected by CVDs and remain underrepresented in global genetic studies.

Objective:

To establish a comprehensive genetic and clinical data repository of individuals with cardiovascular diseases across Asia, focusing on identifying genetic variants and risk profiles unique to Asian populations.

Primary Aim:

To study genetic markers associated with various forms of cardiovascular diseases such as cardiomyopathies, coronary artery disease, arrhythmias, and congenital heart defects in the South Asian population.

Methodology:

This is a prospective, multicentre, observational registry.

Participants will be enrolled from hospitals and cardiology clinics across India (and other Asian countries, if applicable).

Data collected will include demographic details, clinical history, diagnostic test results, ECG, echocardiography, family history, and biological samples (e.g., blood) for genetic analysis.

No interventions or randomization involved.

Data will be anonymized and stored for future research related to cardiovascular genetics.

Target Sample Size: 1000 (or as per your actual protocol)

Study Duration: 5 years

Ethical Considerations:

The study will follow ICMR and GCP guidelines. Ethics Committee approval will be obtained at each participating site. Informed consent will be taken from all participants prior to data and sample collection.