Gastroscopic Esophageal Prick Test in adult Eosinophilic Esophagitis Patients: a pilot study - EPT trial

Academisch Medisch Centrum0 个研究点目标入组 12 人开始时间: 待定最近更新: 2024年6月11日

适应症

试验速览

暂无简介。

•-Previous diagnosis of active EoE confirmed by histopathology e.g. presence of >15 eosinophilic granulocytes per high power field (hpf) in mid or proximal esophageal biopsies
•-Macroscopic disease remission or significant mucosal healing after four weeks of treatment with an elemental or elimination diet
•-Written informed consent
•-Age 18 * 75 years;Healthy control group
•- Written informed consent
•- Age 18 * 75 years
•- Absence of atopic diseases
•- Absence of gastrointestinal symptoms

•- Inability to stop topical corticosteroids
•- Inability to stop beta-blockers and ACE inhibitors
•- Use of oral or systemic antihistaminics, oral cromoglicates, systemic corticosteroids, leukotriene inhibitors, or monoclonal antibodies, in the month preceding the study
•- Proven gastroesophageal reflux disease or other cause for esophageal eosinophilia
•- History of peptic ulcer disease
•- History of Barrett*s esophagus
•- History of GI cancer
•- History of GI tract surgery (except appendectomy)
•- ASA class III, IV or V
•- History of anaphylaxis
•- History of a severe systemic reaction to previous allergy tests (grade 3 or 4);Healthy controls
•- History of atopic diseases
•- Inability to stop beta-blockers and ACE inhibitors
•- Use of oral or systemic antihistaminics, oral cromoglicates, systemic corticosteroids, leukotriene inhibitors, or monoclonal antibodies, in the month preceding the study
•- Proven gastroesophageal reflux disease or other cause for esophageal eosinophilia
•- History of peptic ulcer disease
•- History of Barrett*s esophagus
•- History of GI cancer
•- History of GI tract surgery (except appendectomy)
•- ASA class III, IV or V
•- History of anaphylaxis
•- History of a severe systemic reaction to previous allergy tests (grade 3 or 4)

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