esional and perilesional damage and recovery of the brain after acute ischemic stroke rated by combined 1H- and 31P-Spectroscopy

Not Applicable

Conditions: acute ischemic stroke

Registration Number: DRKS00032960

Lead Sponsor: Klinikum der Goethe-Universität Frankfurt am Main, Institut für Neuroradiologie

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Pending

Sex: All

Target Recruitment: 30

Inclusion Criteria

Subacute ischemic stroke (maximum 1-3 days after acute event)
- demarcated lesion in imaging (DWI, T2w)
- Voluntary participation after being informed of the benefits and risks of the examination
- Written consent of the subject

Exclusion Criteria

- Reduced general condition that does not allow for an examination duration of approximately 45 minutes
- Pregnancy
Implanted electronic devices that do not allow measurement within or in the presence of a magnetic field. This includes implanted pacemakers, neurostimulators, drug pumps, and cochlear implants.
- Magnetizable metal objects within the body (e.g., shards, clips, or staples from surgeries before 1990, metal fragments in the body, such as those acquired from working in the metalworking industry)
- claustrophobia

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
WHAT: This is an exploratory study aimed at analyzing the metabolic processes in damaged brain and surrounding tissue over time. Therefore, multiple spectroscopically measurable parameters are collected (1H spectroscopy: lactate, NAA, glutamine, glutamate, GABA, myoinositol, creatine, choline. 31P spectroscopy: ATP, phosphocreatine, inorganic phosphate, pH, choline, and ethanolamine-containing cell membrane metabolites).<br><br>WHEN: 1-3 days and 8 weeks after acute ischemic stroke.<br><br>HOW: MR spectroscopy.

Secondary Outcome Measures