Development of Systems and Precision Medicine - Take Mood Disorder as an Example.
试验速览
- 阶段
- 不适用
- 入组人数
- 200
- 试验地点
- 1
- 主要终点
- Depression severity
研究概览
简要总结
Precision medicine is to achieve individual optimal health care, given the biological mechanisms, genetic variants, and environmental measurements. Take mood disorder (MD) as an example, we aim to develop systems and precision medicine in Taiwanese population.
MD is a very serious and dysfunctional mental disorder. Since MD patients with treatment have high risk of neurocognitive impairment and metabolic disturbances, the therapeutic strategies are of clinical importance. Individual difference of treatment outcome in MD patients would result from genetic variants, environmental factors, and their interactions. Also, the treatment outcome of MD contains multiple dimensions, including improvement of disease severity, neurocognitive function, and optimized medication strategy. However, comprehensive development of approaches to investigate the multiple dimensions of treatment outcome in MD patients is limited. In this three-year proposal, we explore the interactions of genetic variants and environmental factors (represented by psychosocial stress and gut microbiota) driven approaches to develop precision medicine.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 20 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Male or female patients, 20- 70 years of age
- •Major depression disorder who met the DSM-V diagnostic criteria were enrolled
- •Subjects take at least one kind of antidepressant.
排除标准
- •Pregnant or breast-feeding
- •Presence of any other major psychiatric illness
- •History of substance and alcohol abuse or dependence
- •Presence of auto-immune disorder and infectious diseases
结局指标
主要结局
Depression severity
时间窗: six months
Clinician rated score by Structure Interview Guide for the Hamilton Depression Rating Scale (17-item)
次要结局
- cognitive function assessed using Wisconsin Card Sorting Test (WCST)(six months)
- cognitive function assessed using the Finger Tapping Test (FTT)(six months)
- The influence of environmental factor in mood disorder(six months)
- cognitive function assessed using Continuous Performance Test (CPT)(six months)